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@ARTICLE{Watts:286195,
      author       = {E. L. Watts and T. I. Gonzales and T. Strain and P. F.
                      Saint-Maurice and D. T. Bishop and S. J. Chanock and M.
                      Johansson and T. O. Keku and L. Le Marchand and V. Moreno
                      and P. A. Newcomb and C. C. Newton and R. K. Pai and M. P.
                      Purdue and C. M. Ulrich and K. Smith-Byrne and B. Van
                      Guelpen and F. R. Day and K. Wijndaele and N. J. Wareham and
                      C. E. Matthews and S. C. Moore and S. Brage},
      collaboration = {C. PRACTICAL consortium},
      othercontributors = {R. A. Eeles and C. A. Haiman and Z. Kote-Jarai and F. R.
                          Schumacher and S. Benlloch and A. A. A. Olama and K. R. Muir
                          and S. I. Berndt and D. V. Conti and F. Wiklund and S. J.
                          Chanock and Y. Wang and C. M. Tangen and J. Batra and J. A.
                          Clements and H. Grönberg and N. Pashayan and J. Schleutker
                          and D. Albanes and S. J. Weinstein and A. Wolk and C. M. L.
                          West and L. A. Mucci and G. Cancel-Tassin and S. Koutros and
                          K. D. Sørensen and E. M. Grindedal and D. E. Neal and F. C.
                          Hamdy and J. L. Donovan and R. C. Travis and R. J. Hamilton
                          and S. A. Ingles and B. S. Rosenstein and Y.-J. Lu and G. G.
                          Giles and R. J. MacInnis and A. S. Kibel and A. Vega and M.
                          Kogevinas and K. L. Penney and J. Y. Park and J. L. Stanford
                          and C. Cybulski and B. G. Nordestgaard and S. F. Nielsen and
                          H. Brenner$^*$ and C. Maier and J. Kim and E. M. John and M.
                          R. Teixeira and S. L. Neuhausen and K. De Ruyck and A.
                          Razack and L. F. Newcomb and D. Lessel and R. Kaneva and N.
                          Usmani and F. Claessens and P. A. Townsend and J. E.
                          Castelao and M. J. Roobol and F. Menegaux and K.-T. Khaw and
                          L. Cannon-Albright and H. Pandha and S. N. Thibodeau and D.
                          J. Hunter and P. Kraft and W. J. Blot and E. Riboli},
      title        = {{O}bservational and genetic associations between
                      cardiorespiratory fitness and cancer: a {UK} {B}iobank and
                      international consortia study.},
      journal      = {British journal of cancer},
      volume       = {130},
      number       = {1},
      issn         = {0007-0920},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-02699},
      pages        = {114-124},
      year         = {2024},
      note         = {2024 Jan;130(1):114-124},
      abstract     = {The association of fitness with cancer risk is not clear.We
                      used Cox proportional hazards models to estimate hazard
                      ratios (HRs) and $95\%$ confidence intervals (CIs) for risk
                      of lung, colorectal, endometrial, breast, and prostate
                      cancer in a subset of UK Biobank participants who completed
                      a submaximal fitness test in 2009-12 (N = 72,572). We also
                      investigated relationships using two-sample Mendelian
                      randomisation (MR), odds ratios (ORs) were estimated using
                      the inverse-variance weighted method.After a median of 11
                      years of follow-up, 4290 cancers of interest were diagnosed.
                      A 3.5 ml O2⋅min-1⋅kg-1 total-body mass increase in
                      fitness (equivalent to 1 metabolic equivalent of task (MET),
                      approximately 0.5 standard deviation (SD)) was associated
                      with lower risks of endometrial (HR = 0.81, $95\%$ CI:
                      0.73-0.89), colorectal (0.94, 0.90-0.99), and breast cancer
                      (0.96, 0.92-0.99). In MR analyses, a 0.5 SD increase in
                      genetically predicted O2⋅min-1⋅kg-1 fat-free mass was
                      associated with a lower risk of breast cancer (OR = 0.92,
                      $95\%$ CI: 0.86-0.98). After adjusting for adiposity, both
                      the observational and genetic associations were
                      attenuated.Higher fitness levels may reduce risks of
                      endometrial, colorectal, and breast cancer, though
                      relationships with adiposity are complex and may mediate
                      these relationships. Increasing fitness, including via
                      changes in body composition, may be an effective strategy
                      for cancer prevention.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38057395},
      doi          = {10.1038/s41416-023-02489-3},
      url          = {https://inrepo02.dkfz.de/record/286195},
}