%0 Journal Article
%A Paech, Daniel
%A Weckesser, Nina
%A Franke, Vanessa
%A Breitling, Johannes
%A Görke, Steffen
%A Deike-Hofmann, Katerina
%A Wick, Antje
%A Scherer, Moritz
%A Unterberg, Andreas
%A Wick, Wolfgang
%A Bendszus, Martin
%A Bachert, Peter
%A Ladd, Mark
%A Schlemmer, Heinz-Peter
%A Korzowski, Andreas
%T Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution 31P MR Spectroscopic Imaging at 7.0 T.
%J Radiology / Imaging cancer
%V 6
%N 1
%@ 2638-616X
%C Oak Brook, IL
%I RSNA, Radiological Society of North America
%M DKFZ-2023-02807
%P e220127
%D 2023
%Z #EA:E010#LA:E020#
%X Malignant tumors commonly exhibit a reversed pH gradient compared with normal tissue, with a more acidic extracellular pH and an alkaline intracellular pH (pHi). In this prospective study, pHi values in gliomas were quantified using high-resolution phosphorous 31 (31P) spectroscopic MRI at 7.0 T and were used to correlate pHi alterations with histopathologic findings. A total of 12 participants (mean age, 58 years ± 18 [SD]; seven male, five female) with histopathologically proven, newly diagnosed glioma were included between September 2018 and November 2019. The 31P spectroscopic MRI scans were acquired using a double-resonant 31P/1H phased-array head coil together with a three-dimensional (3D) 31P chemical shift imaging sequence (5.7-mL voxel volume) performed with a 7.0-T whole-body system. The 3D volumetric segmentations were performed for the whole-tumor volumes (WTVs); tumor subcompartments of necrosis, gadolinium enhancement, and nonenhancing T2 (NCE T2) hyperintensity; and normal-appearing white matter (NAWM), and pHi values were compared. Spearman correlation was used to assess association between pHi and the proliferation index Ki-67. For all study participants, mean pHi values were higher in the WTV (7.057 ± 0.024) compared with NAWM (7.006 ± 0.012; P < .001). In eight participants with high-grade gliomas, pHi was increased in all tumor subcompartments (necrosis, 7.075 ± 0.033; gadolinium enhancement, 7.075 ± 0.024; NCE T2 hyperintensity, 7.043 ± 0.015) compared with NAWM (7.004 ± 0.014; all P < .01). The pHi values of WTV positively correlated with Ki-67 (R2 = 0.74, r = 0.78, P = .001). In conclusion, 31P spectroscopic MRI at 7.0 T enabled high-resolution quantification of pHi in gliomas, with pHi alteration associated with the Ki-67 proliferation index, and may aid in diagnosis and treatment monitoring. Keywords: 31P MRSI, pH, Glioma, Glioblastoma, Ultra-High-Field MRI, Imaging Biomarker, 7 Tesla Supplemental material is available for this article. © RSNA, 2023.
%K Male
%K Humans
%K Female
%K Middle Aged
%K Contrast Media
%K Prospective Studies
%K Gadolinium
%K Ki-67 Antigen
%K Brain Neoplasms: diagnostic imaging
%K Glioma: diagnostic imaging
%K Magnetic Resonance Imaging: methods
%K Brain: pathology
%K Necrosis
%K Hydrogen-Ion Concentration
%K 31P MRSI (Other)
%K 7 Tesla (Other)
%K Glioblastoma (Other)
%K Glioma (Other)
%K Imaging Biomarker (Other)
%K Ultra-High-Field MRI (Other)
%K pH (Other)
%K Contrast Media (NLM Chemicals)
%K Gadolinium (NLM Chemicals)
%K Ki-67 Antigen (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38133553
%R 10.1148/rycan.220127
%U https://inrepo02.dkfz.de/record/286590