Journal Article

DKFZ-2023-02807

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Whole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution 31P MR Spectroscopic Imaging at 7.0 T.

Paech, D. (First author)DKFZ* ; Weckesser, N. (First author)DKFZ* ; Franke, V.DKFZ* ; Breitling, J.DKFZ* ; Görke, S.DKFZ* ; Deike-Hofmann, K.DKFZ* ; Wick, A. ; Scherer, M. ; Unterberg, A. ; Wick, W. ; Bendszus, M. ; Bachert, P.DKFZ* ; Ladd, M.DKFZ* ; Schlemmer, H.-P.DKFZ* ; Korzowski, A. (Last author)DKFZ*

2023
RSNA, Radiological Society of North America Oak Brook, IL

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Please use a persistent id in citations: doi:10.1148/rycan.220127

Abstract: Malignant tumors commonly exhibit a reversed pH gradient compared with normal tissue, with a more acidic extracellular pH and an alkaline intracellular pH (pHi). In this prospective study, pHi values in gliomas were quantified using high-resolution phosphorous 31 (31P) spectroscopic MRI at 7.0 T and were used to correlate pHi alterations with histopathologic findings. A total of 12 participants (mean age, 58 years ± 18 [SD]; seven male, five female) with histopathologically proven, newly diagnosed glioma were included between September 2018 and November 2019. The 31P spectroscopic MRI scans were acquired using a double-resonant 31P/1H phased-array head coil together with a three-dimensional (3D) 31P chemical shift imaging sequence (5.7-mL voxel volume) performed with a 7.0-T whole-body system. The 3D volumetric segmentations were performed for the whole-tumor volumes (WTVs); tumor subcompartments of necrosis, gadolinium enhancement, and nonenhancing T2 (NCE T2) hyperintensity; and normal-appearing white matter (NAWM), and pHi values were compared. Spearman correlation was used to assess association between pHi and the proliferation index Ki-67. For all study participants, mean pHi values were higher in the WTV (7.057 ± 0.024) compared with NAWM (7.006 ± 0.012; P < .001). In eight participants with high-grade gliomas, pHi was increased in all tumor subcompartments (necrosis, 7.075 ± 0.033; gadolinium enhancement, 7.075 ± 0.024; NCE T2 hyperintensity, 7.043 ± 0.015) compared with NAWM (7.004 ± 0.014; all P < .01). The pHi values of WTV positively correlated with Ki-67 (R2 = 0.74, r = 0.78, P = .001). In conclusion, 31P spectroscopic MRI at 7.0 T enabled high-resolution quantification of pHi in gliomas, with pHi alteration associated with the Ki-67 proliferation index, and may aid in diagnosis and treatment monitoring. Keywords: 31P MRSI, pH, Glioma, Glioblastoma, Ultra-High-Field MRI, Imaging Biomarker, 7 Tesla Supplemental material is available for this article. © RSNA, 2023.

Keyword(s): Male (MeSH) ; Humans (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Contrast Media (MeSH) ; Prospective Studies (MeSH) ; Gadolinium (MeSH) ; Ki-67 Antigen (MeSH) ; Brain Neoplasms: diagnostic imaging (MeSH) ; Glioma: diagnostic imaging (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Brain: pathology (MeSH) ; Necrosis (MeSH) ; Hydrogen-Ion Concentration (MeSH) ; 31P MRSI ; 7 Tesla ; Glioblastoma ; Glioma ; Imaging Biomarker ; Ultra-High-Field MRI ; pH ; Contrast Media ; Gadolinium ; Ki-67 Antigen

Note: #EA:E010#LA:E020#

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Contributing Institute(s):

1. E010 Radiologie (E010)
2. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Web of Science Core Collection

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