000286590 001__ 286590
000286590 005__ 20240229155126.0
000286590 0247_ $$2doi$$a10.1148/rycan.220127
000286590 0247_ $$2pmid$$apmid:38133553
000286590 0247_ $$2altmetric$$aaltmetric:157720332
000286590 037__ $$aDKFZ-2023-02807
000286590 041__ $$aEnglish
000286590 082__ $$a610
000286590 1001_ $$0P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aPaech, Daniel$$b0$$eFirst author$$udkfz
000286590 245__ $$aWhole-Brain Intracellular pH Mapping of Gliomas Using High-Resolution 31P MR Spectroscopic Imaging at 7.0 T.
000286590 260__ $$aOak Brook, IL$$bRSNA, Radiological Society of North America$$c2023
000286590 3367_ $$2DRIVER$$aarticle
000286590 3367_ $$2DataCite$$aOutput Types/Journal article
000286590 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1703765476_2100
000286590 3367_ $$2BibTeX$$aARTICLE
000286590 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000286590 3367_ $$00$$2EndNote$$aJournal Article
000286590 500__ $$a#EA:E010#LA:E020#
000286590 520__ $$aMalignant tumors commonly exhibit a reversed pH gradient compared with normal tissue, with a more acidic extracellular pH and an alkaline intracellular pH (pHi). In this prospective study, pHi values in gliomas were quantified using high-resolution phosphorous 31 (31P) spectroscopic MRI at 7.0 T and were used to correlate pHi alterations with histopathologic findings. A total of 12 participants (mean age, 58 years ± 18 [SD]; seven male, five female) with histopathologically proven, newly diagnosed glioma were included between September 2018 and November 2019. The 31P spectroscopic MRI scans were acquired using a double-resonant 31P/1H phased-array head coil together with a three-dimensional (3D) 31P chemical shift imaging sequence (5.7-mL voxel volume) performed with a 7.0-T whole-body system. The 3D volumetric segmentations were performed for the whole-tumor volumes (WTVs); tumor subcompartments of necrosis, gadolinium enhancement, and nonenhancing T2 (NCE T2) hyperintensity; and normal-appearing white matter (NAWM), and pHi values were compared. Spearman correlation was used to assess association between pHi and the proliferation index Ki-67. For all study participants, mean pHi values were higher in the WTV (7.057 ± 0.024) compared with NAWM (7.006 ± 0.012; P < .001). In eight participants with high-grade gliomas, pHi was increased in all tumor subcompartments (necrosis, 7.075 ± 0.033; gadolinium enhancement, 7.075 ± 0.024; NCE T2 hyperintensity, 7.043 ± 0.015) compared with NAWM (7.004 ± 0.014; all P < .01). The pHi values of WTV positively correlated with Ki-67 (R2 = 0.74, r = 0.78, P = .001). In conclusion, 31P spectroscopic MRI at 7.0 T enabled high-resolution quantification of pHi in gliomas, with pHi alteration associated with the Ki-67 proliferation index, and may aid in diagnosis and treatment monitoring. Keywords: 31P MRSI, pH, Glioma, Glioblastoma, Ultra-High-Field MRI, Imaging Biomarker, 7 Tesla Supplemental material is available for this article. © RSNA, 2023.
000286590 536__ $$0G:(DE-HGF)POF4-315$$a315 - Bildgebung und Radioonkologie (POF4-315)$$cPOF4-315$$fPOF IV$$x0
000286590 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000286590 650_7 $$2Other$$a31P MRSI
000286590 650_7 $$2Other$$a7 Tesla
000286590 650_7 $$2Other$$aGlioblastoma
000286590 650_7 $$2Other$$aGlioma
000286590 650_7 $$2Other$$aImaging Biomarker
000286590 650_7 $$2Other$$aUltra-High-Field MRI
000286590 650_7 $$2Other$$apH
000286590 650_7 $$2NLM Chemicals$$aContrast Media
000286590 650_7 $$0AU0V1LM3JT$$2NLM Chemicals$$aGadolinium
000286590 650_7 $$2NLM Chemicals$$aKi-67 Antigen
000286590 650_2 $$2MeSH$$aMale
000286590 650_2 $$2MeSH$$aHumans
000286590 650_2 $$2MeSH$$aFemale
000286590 650_2 $$2MeSH$$aMiddle Aged
000286590 650_2 $$2MeSH$$aContrast Media
000286590 650_2 $$2MeSH$$aProspective Studies
000286590 650_2 $$2MeSH$$aGadolinium
000286590 650_2 $$2MeSH$$aKi-67 Antigen
000286590 650_2 $$2MeSH$$aBrain Neoplasms: diagnostic imaging
000286590 650_2 $$2MeSH$$aGlioma: diagnostic imaging
000286590 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000286590 650_2 $$2MeSH$$aBrain: pathology
000286590 650_2 $$2MeSH$$aNecrosis
000286590 650_2 $$2MeSH$$aHydrogen-Ion Concentration
000286590 7001_ $$0P:(DE-He78)e9deaa758e8af7948e97a28aaf0bb7d1$$aWeckesser, Nina$$b1$$eFirst author$$udkfz
000286590 7001_ $$0P:(DE-He78)aa7c5ddf01ae4204a9724ad52583db88$$aFranke, Vanessa$$b2$$udkfz
000286590 7001_ $$0P:(DE-He78)8a54e49721e8ba58de289702bad026d9$$aBreitling, Johannes$$b3
000286590 7001_ $$0P:(DE-He78)802bc375f8583fdb15ccd0abf30c1bfe$$aGörke, Steffen$$b4
000286590 7001_ $$0P:(DE-He78)34255b119acbf293af0239d8f85ce24e$$aDeike-Hofmann, Katerina$$b5
000286590 7001_ $$00000-0003-0020-6386$$aWick, Antje$$b6
000286590 7001_ $$00000-0003-1203-9351$$aScherer, Moritz$$b7
000286590 7001_ $$aUnterberg, Andreas$$b8
000286590 7001_ $$aWick, Wolfgang$$b9
000286590 7001_ $$aBendszus, Martin$$b10
000286590 7001_ $$0P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aBachert, Peter$$b11$$udkfz
000286590 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark$$b12$$udkfz
000286590 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b13$$udkfz
000286590 7001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b14$$eLast author$$udkfz
000286590 773__ $$0PERI:(DE-600)2986040-4$$a10.1148/rycan.220127$$gVol. 6, no. 1, p. e220127$$n1$$pe220127$$tRadiology / Imaging cancer$$v6$$x2638-616X$$y2024
000286590 909CO $$ooai:inrepo02.dkfz.de:286590$$pVDB
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e9deaa758e8af7948e97a28aaf0bb7d1$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)aa7c5ddf01ae4204a9724ad52583db88$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8a54e49721e8ba58de289702bad026d9$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)802bc375f8583fdb15ccd0abf30c1bfe$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)34255b119acbf293af0239d8f85ce24e$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)29b2f01310f7022916255ddba2750f9b$$aDeutsches Krebsforschungszentrum$$b11$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aDeutsches Krebsforschungszentrum$$b12$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aDeutsches Krebsforschungszentrum$$b13$$kDKFZ
000286590 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000286590 9131_ $$0G:(DE-HGF)POF4-315$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vBildgebung und Radioonkologie$$x0
000286590 9141_ $$y2023
000286590 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bRADIOL-IMAG CANCER : 2022$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)0112$$2StatID$$aWoS$$bEmerging Sources Citation Index$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-24
000286590 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-24
000286590 9202_ $$0I:(DE-He78)E020-20160331$$kE020$$lE020 Med. Physik in der Radiologie$$x0
000286590 9201_ $$0I:(DE-He78)E010-20160331$$kE010$$lE010 Radiologie$$x0
000286590 9201_ $$0I:(DE-He78)E020-20160331$$kE020$$lE020 Med. Physik in der Radiologie$$x1
000286590 9200_ $$0I:(DE-He78)E010-20160331$$kE010$$lE010 Radiologie$$x0
000286590 980__ $$ajournal
000286590 980__ $$aVDB
000286590 980__ $$aI:(DE-He78)E010-20160331
000286590 980__ $$aI:(DE-He78)E020-20160331
000286590 980__ $$aUNRESTRICTED