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@ARTICLE{Paech:286590,
      author       = {D. Paech$^*$ and N. Weckesser$^*$ and V. Franke$^*$ and J.
                      Breitling$^*$ and S. Görke$^*$ and K. Deike-Hofmann$^*$ and
                      A. Wick and M. Scherer and A. Unterberg and W. Wick and M.
                      Bendszus and P. Bachert$^*$ and M. Ladd$^*$ and H.-P.
                      Schlemmer$^*$ and A. Korzowski$^*$},
      title        = {{W}hole-{B}rain {I}ntracellular p{H} {M}apping of {G}liomas
                      {U}sing {H}igh-{R}esolution 31{P} {MR} {S}pectroscopic
                      {I}maging at 7.0 {T}.},
      journal      = {Radiology / Imaging cancer},
      volume       = {6},
      number       = {1},
      issn         = {2638-616X},
      address      = {Oak Brook, IL},
      publisher    = {RSNA, Radiological Society of North America},
      reportid     = {DKFZ-2023-02807},
      pages        = {e220127},
      year         = {2023},
      note         = {#EA:E010#LA:E020#},
      abstract     = {Malignant tumors commonly exhibit a reversed pH gradient
                      compared with normal tissue, with a more acidic
                      extracellular pH and an alkaline intracellular pH (pHi). In
                      this prospective study, pHi values in gliomas were
                      quantified using high-resolution phosphorous 31 (31P)
                      spectroscopic MRI at 7.0 T and were used to correlate pHi
                      alterations with histopathologic findings. A total of 12
                      participants (mean age, 58 years ± 18 [SD]; seven male,
                      five female) with histopathologically proven, newly
                      diagnosed glioma were included between September 2018 and
                      November 2019. The 31P spectroscopic MRI scans were acquired
                      using a double-resonant 31P/1H phased-array head coil
                      together with a three-dimensional (3D) 31P chemical shift
                      imaging sequence (5.7-mL voxel volume) performed with a
                      7.0-T whole-body system. The 3D volumetric segmentations
                      were performed for the whole-tumor volumes (WTVs); tumor
                      subcompartments of necrosis, gadolinium enhancement, and
                      nonenhancing T2 (NCE T2) hyperintensity; and
                      normal-appearing white matter (NAWM), and pHi values were
                      compared. Spearman correlation was used to assess
                      association between pHi and the proliferation index Ki-67.
                      For all study participants, mean pHi values were higher in
                      the WTV (7.057 ± 0.024) compared with NAWM (7.006 ± 0.012;
                      P < .001). In eight participants with high-grade gliomas,
                      pHi was increased in all tumor subcompartments (necrosis,
                      7.075 ± 0.033; gadolinium enhancement, 7.075 ± 0.024; NCE
                      T2 hyperintensity, 7.043 ± 0.015) compared with NAWM (7.004
                      ± 0.014; all P < .01). The pHi values of WTV positively
                      correlated with Ki-67 (R2 = 0.74, r = 0.78, P = .001). In
                      conclusion, 31P spectroscopic MRI at 7.0 T enabled
                      high-resolution quantification of pHi in gliomas, with pHi
                      alteration associated with the Ki-67 proliferation index,
                      and may aid in diagnosis and treatment monitoring. Keywords:
                      31P MRSI, pH, Glioma, Glioblastoma, Ultra-High-Field MRI,
                      Imaging Biomarker, 7 Tesla Supplemental material is
                      available for this article. © RSNA, 2023.},
      keywords     = {Male / Humans / Female / Middle Aged / Contrast Media /
                      Prospective Studies / Gadolinium / Ki-67 Antigen / Brain
                      Neoplasms: diagnostic imaging / Glioma: diagnostic imaging /
                      Magnetic Resonance Imaging: methods / Brain: pathology /
                      Necrosis / Hydrogen-Ion Concentration / 31P MRSI (Other) / 7
                      Tesla (Other) / Glioblastoma (Other) / Glioma (Other) /
                      Imaging Biomarker (Other) / Ultra-High-Field MRI (Other) /
                      pH (Other) / Contrast Media (NLM Chemicals) / Gadolinium
                      (NLM Chemicals) / Ki-67 Antigen (NLM Chemicals)},
      cin          = {E010 / E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38133553},
      doi          = {10.1148/rycan.220127},
      url          = {https://inrepo02.dkfz.de/record/286590},
}