TY  - JOUR
AU  - Ratiner, Karina
AU  - Ciocan, Dragos
AU  - Abdeen, Suhaib K
AU  - Elinav, Eran
TI  - Utilization of the microbiome in personalized medicine.
JO  - Nature reviews / Microbiology
VL  - 22
IS  - 5
SN  - 1740-1526
CY  - Basingstoke
PB  - Nature Publ. Group
M1  - DKFZ-2023-02820
SP  - 291-308
PY  - 2024
N1  - #LA:F220# / 2024 May;22(5):291-308
AB  - Inter-individual human variability, driven by various genetic and environmental factors, complicates the ability to develop effective population-based early disease detection, treatment and prognostic assessment. The microbiome, consisting of diverse microorganism communities including viruses, bacteria, fungi and eukaryotes colonizing human body surfaces, has recently been identified as a contributor to inter-individual variation, through its person-specific signatures. As such, the microbiome may modulate disease manifestations, even among individuals with similar genetic disease susceptibility risks. Information stored within microbiomes may therefore enable early detection and prognostic assessment of disease in at-risk populations, whereas microbiome modulation may constitute an effective and safe treatment tailored to the individual. In this Review, we explore recent advances in the application of microbiome data in precision medicine across a growing number of human diseases. We also discuss the challenges, limitations and prospects of analysing microbiome data for personalized patient care.
LB  - PUB:(DE-HGF)16
C6  - pmid:38110694
DO  - DOI:10.1038/s41579-023-00998-9
UR  - https://inrepo02.dkfz.de/record/286608
ER  -