Journal Article (Review Article)

DKFZ-2023-02820

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Utilization of the microbiome in personalized medicine.

Ratiner, K. ; Ciocan, D. ; Abdeen, S. K. ; Elinav, E. (Last author)DKFZ*

2024
Nature Publ. Group Basingstoke

This record in other databases:  

Please use a persistent id in citations: doi:10.1038/s41579-023-00998-9

Abstract: Inter-individual human variability, driven by various genetic and environmental factors, complicates the ability to develop effective population-based early disease detection, treatment and prognostic assessment. The microbiome, consisting of diverse microorganism communities including viruses, bacteria, fungi and eukaryotes colonizing human body surfaces, has recently been identified as a contributor to inter-individual variation, through its person-specific signatures. As such, the microbiome may modulate disease manifestations, even among individuals with similar genetic disease susceptibility risks. Information stored within microbiomes may therefore enable early detection and prognostic assessment of disease in at-risk populations, whereas microbiome modulation may constitute an effective and safe treatment tailored to the individual. In this Review, we explore recent advances in the application of microbiome data in precision medicine across a growing number of human diseases. We also discuss the challenges, limitations and prospects of analysing microbiome data for personalized patient care.

Note: #LA:F220# / 2024 May;22(5):291-308

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Contributing Institute(s):

1. Mikrobiom und Krebs (F220)
2. Mikrobiom und Krebs (D480)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 80 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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