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@ARTICLE{Ratiner:286608,
      author       = {K. Ratiner and D. Ciocan and S. K. Abdeen and E.
                      Elinav$^*$},
      title        = {{U}tilization of the microbiome in personalized medicine.},
      journal      = {Nature reviews / Microbiology},
      volume       = {22},
      number       = {5},
      issn         = {1740-1526},
      address      = {Basingstoke},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-02820},
      pages        = {291-308},
      year         = {2024},
      note         = {#LA:F220# / 2024 May;22(5):291-308},
      abstract     = {Inter-individual human variability, driven by various
                      genetic and environmental factors, complicates the ability
                      to develop effective population-based early disease
                      detection, treatment and prognostic assessment. The
                      microbiome, consisting of diverse microorganism communities
                      including viruses, bacteria, fungi and eukaryotes colonizing
                      human body surfaces, has recently been identified as a
                      contributor to inter-individual variation, through its
                      person-specific signatures. As such, the microbiome may
                      modulate disease manifestations, even among individuals with
                      similar genetic disease susceptibility risks. Information
                      stored within microbiomes may therefore enable early
                      detection and prognostic assessment of disease in at-risk
                      populations, whereas microbiome modulation may constitute an
                      effective and safe treatment tailored to the individual. In
                      this Review, we explore recent advances in the application
                      of microbiome data in precision medicine across a growing
                      number of human diseases. We also discuss the challenges,
                      limitations and prospects of analysing microbiome data for
                      personalized patient care.},
      subtyp        = {Review Article},
      cin          = {F220 / D480},
      ddc          = {610},
      cid          = {I:(DE-He78)F220-20160331 / I:(DE-He78)D480-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38110694},
      doi          = {10.1038/s41579-023-00998-9},
      url          = {https://inrepo02.dkfz.de/record/286608},
}