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000286699 041__ $$aEnglish
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000286699 1001_ $$00000-0002-9023-8068$$aBotteri, Edoardo$$b0
000286699 245__ $$aLifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition.
000286699 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2024
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000286699 500__ $$a2024 Feb;39(2):147-159
000286699 520__ $$aIn this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers-including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others-using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95-0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07-1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65-0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.
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000286699 650_7 $$2Other$$aCancer risk
000286699 650_7 $$2Other$$aCohort study
000286699 650_7 $$2Other$$aHealthy lifestyle index
000286699 650_7 $$2Other$$aLifestyle changes
000286699 7001_ $$aPeveri, Giulia$$b1
000286699 7001_ $$aBerstad, Paula$$b2
000286699 7001_ $$aBagnardi, Vincenzo$$b3
000286699 7001_ $$aHoff, Geir$$b4
000286699 7001_ $$aHeath, Alicia K$$b5
000286699 7001_ $$aCross, Amanda J$$b6
000286699 7001_ $$aVineis, Paolo$$b7
000286699 7001_ $$aDossus, Laure$$b8
000286699 7001_ $$aJohansson, Mattias$$b9
000286699 7001_ $$aFreisling, Heinz$$b10
000286699 7001_ $$aMatta, Komodo$$b11
000286699 7001_ $$aHuybrechts, Inge$$b12
000286699 7001_ $$aChen, Sairah L F$$b13
000286699 7001_ $$aB Borch, Kristin$$b14
000286699 7001_ $$aSandanger, Torkjel M$$b15
000286699 7001_ $$aH Nøst, Therese$$b16
000286699 7001_ $$aDahm, Christina C$$b17
000286699 7001_ $$aAntoniussen, Christian S$$b18
000286699 7001_ $$aTin Tin, Sandar$$b19
000286699 7001_ $$aFournier, Agnès$$b20
000286699 7001_ $$aMarques, Chloé$$b21
000286699 7001_ $$aArtaud, Fanny$$b22
000286699 7001_ $$aSánchez, Maria-José$$b23
000286699 7001_ $$aGuevara, Marcela$$b24
000286699 7001_ $$aSantiuste, Carmen$$b25
000286699 7001_ $$aAgudo, Antonio$$b26
000286699 7001_ $$0P:(DE-He78)0b48ce513fe49013263657450a12f870$$aBajracharya, Rashmita$$b27$$udkfz
000286699 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b28$$udkfz
000286699 7001_ $$aRicceri, Fulvio$$b29
000286699 7001_ $$aAgnoli, Claudia$$b30
000286699 7001_ $$aBergmann, Manuela M$$b31
000286699 7001_ $$aSchulze, Matthias B$$b32
000286699 7001_ $$aPanico, Salvatore$$b33
000286699 7001_ $$aMasala, Giovanna$$b34
000286699 7001_ $$aTjønneland, Anne$$b35
000286699 7001_ $$aOlsen, Anja$$b36
000286699 7001_ $$aStocks, Tanja$$b37
000286699 7001_ $$aManjer, Jonas$$b38
000286699 7001_ $$aAizpurua-Atxega, Amaia$$b39
000286699 7001_ $$aWeiderpass, Elisabete$$b40
000286699 7001_ $$aRiboli, Elio$$b41
000286699 7001_ $$aGunter, Marc J$$b42
000286699 7001_ $$aFerrari, Pietro$$b43
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