Journal Article

DKFZ-2024-00039

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition.

Botteri, E. ; Peveri, G. ; Berstad, P. ; Bagnardi, V. ; Hoff, G. ; Heath, A. K. ; Cross, A. J. ; Vineis, P. ; Dossus, L. ; Johansson, M. ; Freisling, H. ; Matta, K. ; Huybrechts, I. ; Chen, S. L. F. ; B Borch, K. ; Sandanger, T. M. ; H Nøst, T. ; Dahm, C. C. ; Antoniussen, C. S. ; Tin Tin, S. ; Fournier, A. ; Marques, C. ; Artaud, F. ; Sánchez, M.-J. ; Guevara, M. ; Santiuste, C. ; Agudo, A. ; Bajracharya, R.DKFZ* ; Katzke, V.DKFZ* ; Ricceri, F. ; Agnoli, C. ; Bergmann, M. M. ; Schulze, M. B. ; Panico, S. ; Masala, G. ; Tjønneland, A. ; Olsen, A. ; Stocks, T. ; Manjer, J. ; Aizpurua-Atxega, A. ; Weiderpass, E. ; Riboli, E. ; Gunter, M. J. ; Ferrari, P.

2024
Springer Science + Business Media B.V. Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10654-023-01059-4

Abstract: In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers-including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others-using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95-0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07-1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65-0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.

Keyword(s): Cancer risk ; Cohort study ; Healthy lifestyle index ; Lifestyle changes

Note: 2024 Feb;39(2):147-159

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF >= 10 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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