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| 001 | 286699 | ||
| 005 | 20241217142807.0 | ||
| 024 | 7 | _ | |a 10.1007/s10654-023-01059-4 |2 doi |
| 024 | 7 | _ | |a pmid:38180593 |2 pmid |
| 024 | 7 | _ | |a 0393-2990 |2 ISSN |
| 024 | 7 | _ | |a 1573-7284 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2024-00039 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Botteri, Edoardo |0 0000-0002-9023-8068 |b 0 |
| 245 | _ | _ | |a Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition. |
| 260 | _ | _ | |a Dordrecht [u.a.] |c 2024 |b Springer Science + Business Media B.V. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1713784777_12989 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2024 Feb;39(2):147-159 |
| 520 | _ | _ | |a In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers-including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others-using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95-0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07-1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65-0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk. |
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| 650 | _ | 7 | |a Cancer risk |2 Other |
| 650 | _ | 7 | |a Cohort study |2 Other |
| 650 | _ | 7 | |a Healthy lifestyle index |2 Other |
| 650 | _ | 7 | |a Lifestyle changes |2 Other |
| 700 | 1 | _ | |a Peveri, Giulia |b 1 |
| 700 | 1 | _ | |a Berstad, Paula |b 2 |
| 700 | 1 | _ | |a Bagnardi, Vincenzo |b 3 |
| 700 | 1 | _ | |a Hoff, Geir |b 4 |
| 700 | 1 | _ | |a Heath, Alicia K |b 5 |
| 700 | 1 | _ | |a Cross, Amanda J |b 6 |
| 700 | 1 | _ | |a Vineis, Paolo |b 7 |
| 700 | 1 | _ | |a Dossus, Laure |b 8 |
| 700 | 1 | _ | |a Johansson, Mattias |b 9 |
| 700 | 1 | _ | |a Freisling, Heinz |b 10 |
| 700 | 1 | _ | |a Matta, Komodo |b 11 |
| 700 | 1 | _ | |a Huybrechts, Inge |b 12 |
| 700 | 1 | _ | |a Chen, Sairah L F |b 13 |
| 700 | 1 | _ | |a B Borch, Kristin |b 14 |
| 700 | 1 | _ | |a Sandanger, Torkjel M |b 15 |
| 700 | 1 | _ | |a H Nøst, Therese |b 16 |
| 700 | 1 | _ | |a Dahm, Christina C |b 17 |
| 700 | 1 | _ | |a Antoniussen, Christian S |b 18 |
| 700 | 1 | _ | |a Tin Tin, Sandar |b 19 |
| 700 | 1 | _ | |a Fournier, Agnès |b 20 |
| 700 | 1 | _ | |a Marques, Chloé |b 21 |
| 700 | 1 | _ | |a Artaud, Fanny |b 22 |
| 700 | 1 | _ | |a Sánchez, Maria-José |b 23 |
| 700 | 1 | _ | |a Guevara, Marcela |b 24 |
| 700 | 1 | _ | |a Santiuste, Carmen |b 25 |
| 700 | 1 | _ | |a Agudo, Antonio |b 26 |
| 700 | 1 | _ | |a Bajracharya, Rashmita |0 P:(DE-He78)0b48ce513fe49013263657450a12f870 |b 27 |u dkfz |
| 700 | 1 | _ | |a Katzke, Verena |0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |b 28 |u dkfz |
| 700 | 1 | _ | |a Ricceri, Fulvio |b 29 |
| 700 | 1 | _ | |a Agnoli, Claudia |b 30 |
| 700 | 1 | _ | |a Bergmann, Manuela M |b 31 |
| 700 | 1 | _ | |a Schulze, Matthias B |b 32 |
| 700 | 1 | _ | |a Panico, Salvatore |b 33 |
| 700 | 1 | _ | |a Masala, Giovanna |b 34 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 35 |
| 700 | 1 | _ | |a Olsen, Anja |b 36 |
| 700 | 1 | _ | |a Stocks, Tanja |b 37 |
| 700 | 1 | _ | |a Manjer, Jonas |b 38 |
| 700 | 1 | _ | |a Aizpurua-Atxega, Amaia |b 39 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |b 40 |
| 700 | 1 | _ | |a Riboli, Elio |b 41 |
| 700 | 1 | _ | |a Gunter, Marc J |b 42 |
| 700 | 1 | _ | |a Ferrari, Pietro |b 43 |
| 773 | _ | _ | |a 10.1007/s10654-023-01059-4 |0 PERI:(DE-600)2004992-4 |n 2 |p 147-159 |t European journal of epidemiology |v 39 |y 2024 |x 0393-2990 |
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