%0 Journal Article
%A Angelidou, Ioanna Antigoni
%A Stocker, Hannah
%A Beyreuther, Konrad
%A Teichmann, Birgit
%T Validation of the 'Perceptions Regarding pRE-Symptomatic Alzheimer's Disease Screening' (PRE-ADS) Questionnaire in the German Population: Attitudes, Motivations, and Barriers to Pre-Symptomatic Dementia Screening.
%J Journal of Alzheimer's disease
%V 97
%N 1
%@ 1387-2877
%C Amsterdam
%I IOS Press
%M DKFZ-2024-00074
%P 309 - 325
%D 2024
%X Attitudes, motivations, and barriers to pre-symptomatic screening for Alzheimer's disease (AD) in the general population are unclear, and validated measurement tools are lacking.Translation and validation of the German version of the 'Perceptions regarding pRE-symptomatic Alzheimer's Disease Screening' (PRE-ADS) questionnaire.A convenience sample (N = 256) was recruited via an online platform. Validation of the PRE-ADS-D consisted of assessments of reliability, structural validity using Principal Component Analysis (PCA) and Exploratory Factor Analysis (EFA) and construct validity using known-group tests. A subscale 'Acceptability of Screening', with 5 PRE-ADS-D items, was extracted to measure acceptance of screening in clinical practice. The STROBE checklist was used for reporting.EFA revealed a three-factor model for the PRE-ADS-D. Acceptable to good internal consistency was found for the 25-item scale (α= 0.78), as well as for the three factors 'Concerns about Screening' (α= 0.85), 'Intention to be Screened' (α= 0.87), and 'Preventive Health Behaviors' (α= 0.81). Construct validity was confirmed for both the 25-item PRE-ADS-D and the 'Acceptability of Screening' scale (α= 0.91). Overall, 51.2
%K Humans
%K Motivation
%K Alzheimer Disease: diagnosis
%K Reproducibility of Results
%K Asymptomatic Diseases
%K Checklist
%K Alzheimer’s disease (Other)
%K attitude (Other)
%K biomarker (Other)
%K psychometrics (Other)
%K screening (Other)
%K validity (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38189757
%R 10.3233/JAD-230961
%U https://inrepo02.dkfz.de/record/286735