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| Home > Publications database > Validation of the 'Perceptions Regarding pRE-Symptomatic Alzheimer's Disease Screening' (PRE-ADS) Questionnaire in the German Population: Attitudes, Motivations, and Barriers to Pre-Symptomatic Dementia Screening. |
| Home > Publications database > Validation of the 'Perceptions Regarding pRE-Symptomatic Alzheimer's Disease Screening' (PRE-ADS) Questionnaire in the German Population: Attitudes, Motivations, and Barriers to Pre-Symptomatic Dementia Screening. |
| Journal Article | DKFZ-2024-00074 |
; ; ;
2024
IOS Press
Amsterdam
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Please use a persistent id in citations: doi:10.3233/JAD-230961
Abstract: Attitudes, motivations, and barriers to pre-symptomatic screening for Alzheimer's disease (AD) in the general population are unclear, and validated measurement tools are lacking.Translation and validation of the German version of the 'Perceptions regarding pRE-symptomatic Alzheimer's Disease Screening' (PRE-ADS) questionnaire.A convenience sample (N = 256) was recruited via an online platform. Validation of the PRE-ADS-D consisted of assessments of reliability, structural validity using Principal Component Analysis (PCA) and Exploratory Factor Analysis (EFA) and construct validity using known-group tests. A subscale 'Acceptability of Screening', with 5 PRE-ADS-D items, was extracted to measure acceptance of screening in clinical practice. The STROBE checklist was used for reporting.EFA revealed a three-factor model for the PRE-ADS-D. Acceptable to good internal consistency was found for the 25-item scale (α= 0.78), as well as for the three factors 'Concerns about Screening' (α= 0.85), 'Intention to be Screened' (α= 0.87), and 'Preventive Health Behaviors' (α= 0.81). Construct validity was confirmed for both the 25-item PRE-ADS-D and the 'Acceptability of Screening' scale (α= 0.91). Overall, 51.2% of the participants showed a preference for screening. Non-parametric tests were conducted to further explore group differences of the sample.The PRE-ADS-D is a reliable and valid tool to measure attitudes, motives, and barriers regarding pre-symptomatic dementia screening in the German-speaking general population. Additionally, the subscale 'Acceptability of Screening' demonstrated good construct validity and reliability, suggesting its promising potential as a practical tool in clinical practice.
Keyword(s): Humans (MeSH) ; Motivation (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Reproducibility of Results (MeSH) ; Asymptomatic Diseases (MeSH) ; Checklist (MeSH) ; Alzheimer’s disease ; attitude ; biomarker ; psychometrics ; screening ; validity
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