TY  - JOUR
AU  - Angelidou, Ioanna Antigoni
AU  - Stocker, Hannah
AU  - Beyreuther, Konrad
AU  - Teichmann, Birgit
TI  - Validation of the 'Perceptions Regarding pRE-Symptomatic Alzheimer's Disease Screening' (PRE-ADS) Questionnaire in the German Population: Attitudes, Motivations, and Barriers to Pre-Symptomatic Dementia Screening.
JO  - Journal of Alzheimer's disease
VL  - 97
IS  - 1
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DKFZ-2024-00074
SP  - 309 - 325
PY  - 2024
AB  - Attitudes, motivations, and barriers to pre-symptomatic screening for Alzheimer's disease (AD) in the general population are unclear, and validated measurement tools are lacking.Translation and validation of the German version of the 'Perceptions regarding pRE-symptomatic Alzheimer's Disease Screening' (PRE-ADS) questionnaire.A convenience sample (N = 256) was recruited via an online platform. Validation of the PRE-ADS-D consisted of assessments of reliability, structural validity using Principal Component Analysis (PCA) and Exploratory Factor Analysis (EFA) and construct validity using known-group tests. A subscale 'Acceptability of Screening', with 5 PRE-ADS-D items, was extracted to measure acceptance of screening in clinical practice. The STROBE checklist was used for reporting.EFA revealed a three-factor model for the PRE-ADS-D. Acceptable to good internal consistency was found for the 25-item scale (α= 0.78), as well as for the three factors 'Concerns about Screening' (α= 0.85), 'Intention to be Screened' (α= 0.87), and 'Preventive Health Behaviors' (α= 0.81). Construct validity was confirmed for both the 25-item PRE-ADS-D and the 'Acceptability of Screening' scale (α= 0.91). Overall, 51.2
KW  - Humans
KW  - Motivation
KW  - Alzheimer Disease: diagnosis
KW  - Reproducibility of Results
KW  - Asymptomatic Diseases
KW  - Checklist
KW  - Alzheimer’s disease (Other)
KW  - attitude (Other)
KW  - biomarker (Other)
KW  - psychometrics (Other)
KW  - screening (Other)
KW  - validity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38189757
DO  - DOI:10.3233/JAD-230961
UR  - https://inrepo02.dkfz.de/record/286735
ER  -