%0 Journal Article
%A Scholz, Markus
%A Horn, Katrin
%A Pott, Janne
%A Wuttke, Matthias
%A Kühnapfel, Andreas
%A Nasr, M Kamal
%A Kirsten, Holger
%A Li, Yong
%A Hoppmann, Anselm
%A Gorski, Mathias
%A Ghasemi, Sahar
%A Li, Man
%A Tin, Adrienne
%A Chai, Jin-Fang
%A Cocca, Massimiliano
%A Wang, Judy
%A Nutile, Teresa
%A Akiyama, Masato
%A Åsvold, Bjørn Olav
%A Bansal, Nisha
%A Biggs, Mary L
%A Boutin, Thibaud
%A Brenner, Hermann
%A Brumpton, Ben
%A Burkhardt, Ralph
%A Cai, Jianwen
%A Campbell, Archie
%A Campbell, Harry
%A Chalmers, John
%A Chasman, Daniel I
%A Chee, Miao Ling
%A Chee, Miao Li
%A Chen, Xu
%A Cheng, Ching-Yu
%A Cifkova, Renata
%A Daviglus, Martha
%A Delgado, Graciela
%A Dittrich, Katalin
%A Edwards, Todd L
%A Endlich, Karlhans
%A Michael Gaziano, J.
%A Giri, Ayush
%A Giulianini, Franco
%A Gordon, Scott D
%A Gudbjartsson, Daniel F
%A Hallan, Stein
%A Hamet, Pavel
%A Hartman, Catharina A
%A Hayward, Caroline
%A Heid, Iris M
%A Hellwege, Jacklyn N
%A Holleczek, Bernd
%A Holm, Hilma
%A Hutri-Kähönen, Nina
%A Hveem, Kristian
%A Isermann, Berend
%A Jonas, Jost B
%A Joshi, Peter K
%A Kamatani, Yoichiro
%A Kanai, Masahiro
%A Kastarinen, Mika
%A Khor, Chiea Chuen
%A Kiess, Wieland
%A Kleber, Marcus E
%A Körner, Antje
%A Kovacs, Peter
%A Krajcoviechova, Alena
%A Kramer, Holly
%A Krämer, Bernhard K
%A Kuokkanen, Mikko
%A Kähönen, Mika
%A Lange, Leslie A
%A Lash, James P
%A Lehtimäki, Terho
%A Li, Hengtong
%A Lin, Bridget M
%A Liu, Jianjun
%A Loeffler, Markus
%A Lyytikäinen, Leo-Pekka
%A Magnusson, Patrik K E
%A Martin, Nicholas G
%A Matsuda, Koichi
%A Milaneschi, Yuri
%A Mishra, Pashupati P
%A Mononen, Nina
%A Montgomery, Grant W
%A Mook-Kanamori, Dennis O
%A Mychaleckyj, Josyf C
%A März, Winfried
%A Nauck, Matthias
%A Nikus, Kjell
%A Nolte, Ilja M
%A Noordam, Raymond
%A Okada, Yukinori
%A Olafsson, Isleifur
%A Oldehinkel, Albertine J
%A Penninx, Brenda W J H
%A Perola, Markus
%A Pirastu, Nicola
%A Polasek, Ozren
%A Porteous, David J
%A Poulain, Tanja
%A Psaty, Bruce M
%A Rabelink, Ton J
%A Raffield, Laura M
%A Raitakari, Olli T
%A Rasheed, Humaira
%A Reilly, Dermot F
%A Rice, Kenneth M
%A Richmond, Anne
%A Ridker, Paul M
%A Rotter, Jerome I
%A Rudan, Igor
%A Sabanayagam, Charumathi
%A Salomaa, Veikko
%A Schneiderman, Neil
%A Schöttker, Ben
%A Sims, Mario
%A Snieder, Harold
%A Stark, Klaus J
%A Stefansson, Kari
%A Stocker, Hannah
%A Stumvoll, Michael
%A Sulem, Patrick
%A Sveinbjornsson, Gardar
%A Svensson, Per O
%A Tai, E-Shyong
%A Taylor, Kent D
%A Tayo, Bamidele O
%A Teren, Andrej
%A Tham, Yih-Chung
%A Thiery, Joachim
%A Thio, Chris H L
%A Thomas, Laurent F
%A Tremblay, Johanne
%A Tönjes, Anke
%A van der Most, Peter J
%A Vitart, Veronique
%A Völker, Uwe
%A Wang, Ya Xing
%A Wang, Chaolong
%A Wei, Wen Bin
%A Whitfield, John B
%A Wild, Sarah H
%A Wilson, James F
%A Winkler, Thomas W
%A Wong, Tien-Yin
%A Woodward, Mark
%A Sim, Xueling
%A Chu, Audrey Y
%A Feitosa, Mary F
%A Thorsteinsdottir, Unnur
%A Hung, Adriana M
%A Teumer, Alexander
%A Franceschini, Nora
%A Parsa, Afshin
%A Köttgen, Anna
%A Schlosser, Pascal
%A Pattaro, Cristian
%T X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.
%J Nature Communications
%V 15
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2024-00159
%P 586
%D 2024
%X X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38233393
%R 10.1038/s41467-024-44709-1
%U https://inrepo02.dkfz.de/record/287064