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@ARTICLE{Thomas:287267,
      author       = {C. E. Thomas and P. Georgeson and C. Qu and R. S.
                      Steinfelder and D. D. Buchanan and M. Song and T. A.
                      Harrison and C. Y. Um and M. A. Hullar and M. A. Jenkins and
                      B. Van Guelpen and B. M. Lynch and Y. A. Melaku and J. R.
                      Huyghe and E. K. Aglago and S. I. Berndt and L. A. Boardman
                      and P. T. Campbell and Y. Cao and A. T. Chan and D. A. Drew
                      and J. C. Figueiredo and A. J. French and M. Giannakis and
                      E. L. Goode and S. B. Gruber and A. Gsur and M. J. Gunter
                      and M. Hoffmeister$^*$ and L. Hsu and W.-Y. Huang and V.
                      Moreno and N. Murphy and P. A. Newcomb and C. C. Newton and
                      J. A. Nowak and M. Obón-Santacana and S. Ogino and W. Sun
                      and A. E. Toland and Q. M. Trinh and T. Ugai and S. H. Zaidi
                      and U. Peters and A. I. Phipps},
      title        = {{E}pidemiologic factors in relation to colorectal cancer
                      risk and survival by genotoxic colibactin mutational
                      signature.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {33},
      number       = {4},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2024-00199},
      pages        = {534-546},
      year         = {2024},
      note         = {2024 Apr 3;33(4):534-546},
      abstract     = {The genotoxin colibactin causes a tumor single base
                      substitution (SBS) mutational signature, SBS88. It is
                      unknown whether epidemiologic factors association with
                      colorectal cancer (CRC) risk and survival differ by
                      SBS88.Within the Genetic Epidemiology of Colorectal Cancer
                      Consortium and Colon Cancer Family Registry, we measured
                      SBS88 in 4,308 microsatellite stable/microsatellite
                      instability low tumors. Associations of epidemiologic
                      factors with CRC risk by SBS88 were assessed using
                      multinomial regression (N=4,308 cases, 14,192 controls;
                      cohort-only cases N=1,911), and with CRC-specific survival
                      using Cox proportional hazards regression (N=3,465
                      cases).392 $(9\%)$ tumors were SBS88 positive. Among all
                      cases, the highest quartile of fruit intake was associated
                      with lower risk of SBS88-positive CRC than SBS88-negative
                      CRC [odds ratio (OR) = 0.53, $95\%$ confidence interval (CI)
                      0.37, 0.76; OR = 0.75, $95\%$ CI 0.66, 0.85, respectively,
                      Pheterogeneity = 0.047]. Among cohort studies, associations
                      of BMI, alcohol, and fruit intake with CRC risk differed by
                      SBS88. BMI ≥30 kg/m2 was associated with worse
                      CRC-specific survival among those SBS88-positive [hazard
                      ratio (HR) = 3.40, $95\%$ CI 1.47, 7.84], but not among
                      those SBS88-negative (HR = 0.97, $95\%$ CI 0.78, 1.21,
                      Pheterogeneity = 0.066).Most epidemiologic factors did not
                      differ by SBS88 for CRC risk or survival. Higher BMI may be
                      associated with worse CRC-specific survival among those
                      SBS88-positive, however validation is needed in samples with
                      whole-genome or exome sequencing available.This study
                      highlights the importance of identification of tumor
                      phenotypes related to CRC and understanding potential
                      heterogeneity for risk and survival.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38252034},
      doi          = {10.1158/1055-9965.EPI-23-0600},
      url          = {https://inrepo02.dkfz.de/record/287267},
}