Journal Article

DKFZ-2024-00199

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Epidemiologic factors in relation to colorectal cancer risk and survival by genotoxic colibactin mutational signature.

Thomas, C. E. ; Georgeson, P. ; Qu, C. ; Steinfelder, R. S. ; Buchanan, D. D. ; Song, M. ; Harrison, T. A. ; Um, C. Y. ; Hullar, M. A. ; Jenkins, M. A. ; Van Guelpen, B. ; Lynch, B. M. ; Melaku, Y. A. ; Huyghe, J. R. ; Aglago, E. K. ; Berndt, S. I. ; Boardman, L. A. ; Campbell, P. T. ; Cao, Y. ; Chan, A. T. ; Drew, D. A. ; Figueiredo, J. C. ; French, A. J. ; Giannakis, M. ; Goode, E. L. ; Gruber, S. B. ; Gsur, A. ; Gunter, M. J. ; Hoffmeister, M.DKFZ* ; Hsu, L. ; Huang, W.-Y. ; Moreno, V. ; Murphy, N. ; Newcomb, P. A. ; Newton, C. C. ; Nowak, J. A. ; Obón-Santacana, M. ; Ogino, S. ; Sun, W. ; Toland, A. E. ; Trinh, Q. M. ; Ugai, T. ; Zaidi, S. H. ; Peters, U. ; Phipps, A. I.

2024
AACR Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1158/1055-9965.EPI-23-0600

Abstract: The genotoxin colibactin causes a tumor single base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors association with colorectal cancer (CRC) risk and survival differ by SBS88.Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with CRC risk by SBS88 were assessed using multinomial regression (N=4,308 cases, 14,192 controls; cohort-only cases N=1,911), and with CRC-specific survival using Cox proportional hazards regression (N=3,465 cases).392 (9%) tumors were SBS88 positive. Among all cases, the highest quartile of fruit intake was associated with lower risk of SBS88-positive CRC than SBS88-negative CRC [odds ratio (OR) = 0.53, 95% confidence interval (CI) 0.37, 0.76; OR = 0.75, 95% CI 0.66, 0.85, respectively, Pheterogeneity = 0.047]. Among cohort studies, associations of BMI, alcohol, and fruit intake with CRC risk differed by SBS88. BMI ≥30 kg/m2 was associated with worse CRC-specific survival among those SBS88-positive [hazard ratio (HR) = 3.40, 95% CI 1.47, 7.84], but not among those SBS88-negative (HR = 0.97, 95% CI 0.78, 1.21, Pheterogeneity = 0.066).Most epidemiologic factors did not differ by SBS88 for CRC risk or survival. Higher BMI may be associated with worse CRC-specific survival among those SBS88-positive, however validation is needed in samples with whole-genome or exome sequencing available.This study highlights the importance of identification of tumor phenotypes related to CRC and understanding potential heterogeneity for risk and survival.

Note: 2024 Apr 3;33(4):534-546

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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