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@ARTICLE{Wang:287296,
      author       = {C. Wang$^*$ and M. Sun and C. Shao$^*$ and L. Schlicker and
                      Y. Zhuo$^*$ and Y. Harim$^*$ and T. Peng and W. Tian$^*$ and
                      N. Stöffler$^*$ and M. Schneider$^*$ and D. Helm$^*$ and Y.
                      Chu and B. Fu and X. Jin and J.-P. Mallm$^*$ and M. Mall$^*$
                      and Y. Wu and A. Schulze$^*$ and H. Liu$^*$},
      title        = {{A} multidimensional atlas of human glioblastoma-like
                      organoids reveals highly coordinated molecular networks and
                      effective drugs.},
      journal      = {npj precision oncology},
      volume       = {8},
      number       = {1},
      issn         = {2397-768X},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2024-00216},
      pages        = {19},
      year         = {2024},
      note         = {DKFZ-ZMBH alliance / #EA:A240#LA:A240#},
      abstract     = {Recent advances in the genomics of glioblastoma (GBM) led
                      to the introduction of molecular neuropathology but failed
                      to translate into treatment improvement. This is largely
                      attributed to the genetic and phenotypic heterogeneity of
                      GBM, which are considered the major obstacle to GBM therapy.
                      Here, we use advanced human GBM-like organoid (LEGO:
                      Laboratory Engineered Glioblastoma-like Organoid) models and
                      provide an unprecedented comprehensive characterization of
                      LEGO models using single-cell transcriptome, DNA methylome,
                      metabolome, lipidome, proteome, and phospho-proteome
                      analysis. We discovered that genetic heterogeneity dictates
                      functional heterogeneity across molecular layers and
                      demonstrates that NF1 mutation drives mesenchymal signature.
                      Most importantly, we found that glycerol lipid reprogramming
                      is a hallmark of GBM, and several targets and drugs were
                      discovered along this line. We also provide a genotype-based
                      drug reference map using LEGO-based drug screen. This study
                      provides new human GBM models and a research path toward
                      effective GBM therapy.},
      cin          = {A240 / W120 / W192 / A340},
      ddc          = {610},
      cid          = {I:(DE-He78)A240-20160331 / I:(DE-He78)W120-20160331 /
                      I:(DE-He78)W192-20160331 / I:(DE-He78)A340-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38273014},
      doi          = {10.1038/s41698-024-00500-5},
      url          = {https://inrepo02.dkfz.de/record/287296},
}