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@ARTICLE{Helderman:289122,
      author       = {N. C. Helderman and M. E. van Leerdam and M. Kloor$^*$ and
                      A. Ahadova$^*$ and M. Nielsen},
      title        = {{E}merge of colorectal cancer in {L}ynch syndrome despite
                      colonoscopy surveillance: {A} challenge of hide and seek.},
      journal      = {Critical reviews in oncology, hematology},
      volume       = {197},
      issn         = {0737-9587},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2024-00589},
      pages        = {104331},
      year         = {2024},
      abstract     = {Even with colonoscopy surveillance, Lynch syndromes (LS)
                      carriers still develop colorectal cancer (CRC). The
                      cumulative incidence of CRCs under colonoscopy surveillance
                      varies depending on the affected mismatch repair (MMR) gene.
                      However, the precise mechanisms driving these
                      epidemiological patterns remain incompletely understood. In
                      recent years, several potential mechanisms explaining the
                      occurrence of CRCs during colonoscopy surveillance have been
                      proposed in individuals with and without LS. These encompass
                      biological factors like concealed/accelerated carcinogenesis
                      through a bypassed adenoma stage and accelerated progression
                      from adenomas. Alongside these, various colonoscopy-related
                      factors may contribute to formation of CRCs under
                      colonoscopy surveillance, like missed yet detectable
                      (pre)cancerous lesions, detected yet incompletely removed
                      (pre)cancerous lesions, and colonoscopy-induced
                      carcinogenesis due to tumor cell reimplantation. In this
                      comprehensive literature update, we reviewed these potential
                      factors and evaluated their relevance to each MMR group in
                      an attempt to raise further awareness and stimulate research
                      regarding this conflicting phenomenon.},
      subtyp        = {Review Article},
      keywords     = {Colonoscopy surveillance (Other) / Colorectal cancer
                      (Other) / Incident colorectal cancer (Other) / Lynch
                      syndrome (Other) / Mismatch repair (Other) /
                      Post-colonoscopy colorectal cancer (Other)},
      cin          = {F210 / D470},
      ddc          = {610},
      cid          = {I:(DE-He78)F210-20160331 / I:(DE-He78)D470-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38521284},
      doi          = {10.1016/j.critrevonc.2024.104331},
      url          = {https://inrepo02.dkfz.de/record/289122},
}