Journal Article (Review Article)

DKFZ-2024-00589

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Emerge of colorectal cancer in Lynch syndrome despite colonoscopy surveillance: A challenge of hide and seek.

Helderman, N. C. ; van Leerdam, M. E. ; Kloor, M.DKFZ* ; Ahadova, A.DKFZ* ; Nielsen, M.

2024
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.critrevonc.2024.104331

Abstract: Even with colonoscopy surveillance, Lynch syndromes (LS) carriers still develop colorectal cancer (CRC). The cumulative incidence of CRCs under colonoscopy surveillance varies depending on the affected mismatch repair (MMR) gene. However, the precise mechanisms driving these epidemiological patterns remain incompletely understood. In recent years, several potential mechanisms explaining the occurrence of CRCs during colonoscopy surveillance have been proposed in individuals with and without LS. These encompass biological factors like concealed/accelerated carcinogenesis through a bypassed adenoma stage and accelerated progression from adenomas. Alongside these, various colonoscopy-related factors may contribute to formation of CRCs under colonoscopy surveillance, like missed yet detectable (pre)cancerous lesions, detected yet incompletely removed (pre)cancerous lesions, and colonoscopy-induced carcinogenesis due to tumor cell reimplantation. In this comprehensive literature update, we reviewed these potential factors and evaluated their relevance to each MMR group in an attempt to raise further awareness and stimulate research regarding this conflicting phenomenon.

Keyword(s): Colonoscopy surveillance ; Colorectal cancer ; Incident colorectal cancer ; Lynch syndrome ; Mismatch repair ; Post-colonoscopy colorectal cancer

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Contributing Institute(s):

1. KKE Angewandte Tumorbiologie (F210)
2. KKE Angewandte Tumorbiologie (D470)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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