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000289132 1001_ $$aStreit, Fabian$$b0
000289132 245__ $$aThe interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).
000289132 260__ $$aLausanne$$bFrontiers Media$$c2023
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000289132 520__ $$aFamily history of depression and childhood maltreatment are established risk factors for depression. However, how these factors are interrelated and jointly influence depression risk is not well understood. The present study investigated (i) if childhood maltreatment is associated with a family history of depression (ii) if family history and childhood maltreatment are associated with increased lifetime and current depression, and whether both factors interact beyond their main effects, and (iii) if family history affects lifetime and current depression via childhood maltreatment.Analyses were based on a subgroup of the first 100,000 participants of the German National Cohort (NAKO), with complete information (58,703 participants, mean age = 51.2 years, 53% female). Parental family history of depression was assessed via self-report, childhood maltreatment with the Childhood Trauma Screener (CTS), lifetime depression with self-reported physician's diagnosis and the Mini-International Neuropsychiatric Interview (MINI), and current depressive symptoms with the depression scale of the Patient Health Questionnaire (PHQ-9). Generalized linear models were used to test main and interaction effects. Mediation was tested using causal mediation analyses.Higher frequencies of the childhood maltreatment measures were found in subjects reporting a positive family history of depression. Family history and childhood maltreatment were independently associated with increased depression. No statistical interactions of family history and childhood maltreatment were found for the lifetime depression measures. For current depressive symptoms (PHQ-9 sum score), an interaction was found, with stronger associations of childhood maltreatment and depression in subjects with a positive family history. Childhood maltreatment was estimated to mediate 7%-12% of the effect of family history on depression, with higher mediated proportions in subjects whose parents had a depression onset below 40 years. Abuse showed stronger associations with family history and depression, and higher mediated proportions of family history effects on depression than neglect.The present study confirms the association of childhood maltreatment and family history with depression in a large population-based cohort. While analyses provide little evidence for the joint effects of both risk factors on depression beyond their individual effects, results are consistent with family history affecting depression via childhood maltreatment to a small extent.
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000289132 650_7 $$2Other$$aabuse
000289132 650_7 $$2Other$$achildhood trauma
000289132 650_7 $$2Other$$adepression
000289132 650_7 $$2Other$$afamily history
000289132 650_7 $$2Other$$agenetics
000289132 650_7 $$2Other$$amaltreatment
000289132 650_7 $$2Other$$aneglect
000289132 7001_ $$aVölker, Maja P$$b1
000289132 7001_ $$aKlinger-König, Johanna$$b2
000289132 7001_ $$aZillich, Lea$$b3
000289132 7001_ $$aFrank, Josef$$b4
000289132 7001_ $$aReinhard, Iris$$b5
000289132 7001_ $$aFoo, Jerome C$$b6
000289132 7001_ $$aWitt, Stephanie H$$b7
000289132 7001_ $$aSirignano, Lea$$b8
000289132 7001_ $$aBecher, Heiko$$b9
000289132 7001_ $$aObi, Nadia$$b10
000289132 7001_ $$aRiedel, Oliver$$b11
000289132 7001_ $$aDo, Stefanie$$b12
000289132 7001_ $$aCastell, Stefanie$$b13
000289132 7001_ $$aHassenstein, Max J$$b14
000289132 7001_ $$aKarch, André$$b15
000289132 7001_ $$aStang, Andreas$$b16
000289132 7001_ $$aSchmidt, Börge$$b17
000289132 7001_ $$aSchikowski, Tamara$$b18
000289132 7001_ $$aStahl-Pehe, Anna$$b19
000289132 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b20$$udkfz
000289132 7001_ $$aPerna, Laura$$b21
000289132 7001_ $$0P:(DE-He78)e0ac0d57cdb66d87f2d95ae5f6178c1b$$aGreiser, Karin Halina$$b22$$udkfz
000289132 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b23$$udkfz
000289132 7001_ $$aMichels, Karin B$$b24
000289132 7001_ $$aFranzke, Claus-Werner$$b25
000289132 7001_ $$aPeters, Annette$$b26
000289132 7001_ $$aFischer, Beate$$b27
000289132 7001_ $$aKonzok, Julian$$b28
000289132 7001_ $$aMikolajczyk, Rafael$$b29
000289132 7001_ $$aFührer, Amand$$b30
000289132 7001_ $$aKeil, Thomas$$b31
000289132 7001_ $$aFricke, Julia$$b32
000289132 7001_ $$aWillich, Stefan N$$b33
000289132 7001_ $$aPischon, Tobias$$b34
000289132 7001_ $$aVölzke, Henry$$b35
000289132 7001_ $$aMeinke-Franze, Claudia$$b36
000289132 7001_ $$aLoeffler, Markus$$b37
000289132 7001_ $$aWirkner, Kerstin$$b38
000289132 7001_ $$aBerger, Klaus$$b39
000289132 7001_ $$aGrabe, Hans J$$b40
000289132 7001_ $$aRietschel, Marcella$$b41
000289132 773__ $$0PERI:(DE-600)3106325-1$$a10.3389/fepid.2023.1099235$$gVol. 3, p. 1099235$$p1099235$$tFrontiers in epidemiology$$v3$$x2674-1199$$y2023
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