Journal Article

DKFZ-2024-00599

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).

Streit, F. ; Völker, M. P. ; Klinger-König, J. ; Zillich, L. ; Frank, J. ; Reinhard, I. ; Foo, J. C. ; Witt, S. H. ; Sirignano, L. ; Becher, H. ; Obi, N. ; Riedel, O. ; Do, S. ; Castell, S. ; Hassenstein, M. J. ; Karch, A. ; Stang, A. ; Schmidt, B. ; Schikowski, T. ; Stahl-Pehe, A. ; Brenner, H.DKFZ* ; Perna, L. ; Greiser, K. H.DKFZ* ; Kaaks, R.DKFZ* ; Michels, K. B. ; Franzke, C.-W. ; Peters, A. ; Fischer, B. ; Konzok, J. ; Mikolajczyk, R. ; Führer, A. ; Keil, T. ; Fricke, J. ; Willich, S. N. ; Pischon, T. ; Völzke, H. ; Meinke-Franze, C. ; Loeffler, M. ; Wirkner, K. ; Berger, K. ; Grabe, H. J. ; Rietschel, M.

2023
Frontiers Media Lausanne

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Please use a persistent id in citations: doi:10.3389/fepid.2023.1099235

Abstract: Family history of depression and childhood maltreatment are established risk factors for depression. However, how these factors are interrelated and jointly influence depression risk is not well understood. The present study investigated (i) if childhood maltreatment is associated with a family history of depression (ii) if family history and childhood maltreatment are associated with increased lifetime and current depression, and whether both factors interact beyond their main effects, and (iii) if family history affects lifetime and current depression via childhood maltreatment.Analyses were based on a subgroup of the first 100,000 participants of the German National Cohort (NAKO), with complete information (58,703 participants, mean age = 51.2 years, 53% female). Parental family history of depression was assessed via self-report, childhood maltreatment with the Childhood Trauma Screener (CTS), lifetime depression with self-reported physician's diagnosis and the Mini-International Neuropsychiatric Interview (MINI), and current depressive symptoms with the depression scale of the Patient Health Questionnaire (PHQ-9). Generalized linear models were used to test main and interaction effects. Mediation was tested using causal mediation analyses.Higher frequencies of the childhood maltreatment measures were found in subjects reporting a positive family history of depression. Family history and childhood maltreatment were independently associated with increased depression. No statistical interactions of family history and childhood maltreatment were found for the lifetime depression measures. For current depressive symptoms (PHQ-9 sum score), an interaction was found, with stronger associations of childhood maltreatment and depression in subjects with a positive family history. Childhood maltreatment was estimated to mediate 7%-12% of the effect of family history on depression, with higher mediated proportions in subjects whose parents had a depression onset below 40 years. Abuse showed stronger associations with family history and depression, and higher mediated proportions of family history effects on depression than neglect.The present study confirms the association of childhood maltreatment and family history with depression in a large population-based cohort. While analyses provide little evidence for the joint effects of both risk factors on depression beyond their individual effects, results are consistent with family history affecting depression via childhood maltreatment to a small extent.

Keyword(s): abuse ; childhood trauma ; depression ; family history ; genetics ; maltreatment ; neglect

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2023

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