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@ARTICLE{BarZiv:289206,
      author       = {O. Bar Ziv and A. Cahn and T. Jansen and V. Istomin and E.
                      Kedem and K. Olshtain-Pops and S. Israel and Y. Oster and E.
                      Orenbuch-Harroch and M. Korem and J. Strahilevitz and I.
                      Levy and R. Valdés-Mas and V. Ivanova and E. Elinav$^*$ and
                      E. Shahar and H. Elinav},
      title        = {{D}iagnosis and {R}isk {F}actors of {P}rediabetes and
                      {D}iabetes in {P}eople {L}iving with {HIV}- {E}valuation of
                      {C}linical and {M}icrobiome {P}arameters.},
      journal      = {The journal of infectious diseases},
      volume       = {230},
      number       = {2},
      issn         = {0022-1899},
      address      = {Oxford [u.a.]},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2024-00640},
      pages        = {411-420},
      year         = {2024},
      note         = {2024 Aug 16;230(2):411-420},
      abstract     = {Diabetes is more common among people living with HIV
                      (PLWH), as compared with healthy individuals. In a
                      prospective multicenter study (N = 248), we identified
                      normoglycemic $(48.7\%),$ prediabetic $(44.4\%)$ and
                      diabetic $(6.9\%)$ PLWH. HbA1c and fasting blood glucose
                      (FBG) sensitivity in defining dysglycemia was $96.8\%,$
                      while addition of oral glucose tolerance test led to
                      reclassification of only 4 patients. Inclusion of 93
                      additional PLWH with known DM enabled identification of
                      multiple independent predictors of dysglycemia or diabetes:
                      older age, higher BMI, Ethiopian origin, HIV duration, lower
                      integrase inhibitor exposure and advanced disease at
                      diagnosis. Shotgun metagenomic microbiome analysis revealed
                      4 species that were significantly expanded with
                      hyperglycemia/hyperinsulinemia, and 2 species that were
                      differentially more prevalent in prediabetic/diabetic PLWH.
                      Collectively, we uncover multiple potential host and
                      microbiome predictors of altered glycemic status in PLWH,
                      while demonstrating that FBG and HbA1C likely suffice for
                      diabetes screening. These potential diabetic predictors
                      merit future prospective validation.},
      keywords     = {HIV/AIDS (Other) / Prediction and Prevention (Other) / Type
                      2 Diabetes (Other) / microbiome (Other) / prediabetes
                      (Other)},
      cin          = {F220 / D480},
      ddc          = {610},
      cid          = {I:(DE-He78)F220-20160331 / I:(DE-He78)D480-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38557867},
      doi          = {10.1093/infdis/jiae167},
      url          = {https://inrepo02.dkfz.de/record/289206},
}