Journal Article

DKFZ-2024-00640

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diagnosis and Risk Factors of Prediabetes and Diabetes in People Living with HIV- Evaluation of Clinical and Microbiome Parameters.

Bar Ziv, O. ; Cahn, A. ; Jansen, T. ; Istomin, V. ; Kedem, E. ; Olshtain-Pops, K. ; Israel, S. ; Oster, Y. ; Orenbuch-Harroch, E. ; Korem, M. ; Strahilevitz, J. ; Levy, I. ; Valdés-Mas, R. ; Ivanova, V. ; Elinav, E.DKFZ* ; Shahar, E. ; Elinav, H.

2024
Oxford Univ. Press Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1093/infdis/jiae167

Abstract: Diabetes is more common among people living with HIV (PLWH), as compared with healthy individuals. In a prospective multicenter study (N = 248), we identified normoglycemic (48.7%), prediabetic (44.4%) and diabetic (6.9%) PLWH. HbA1c and fasting blood glucose (FBG) sensitivity in defining dysglycemia was 96.8%, while addition of oral glucose tolerance test led to reclassification of only 4 patients. Inclusion of 93 additional PLWH with known DM enabled identification of multiple independent predictors of dysglycemia or diabetes: older age, higher BMI, Ethiopian origin, HIV duration, lower integrase inhibitor exposure and advanced disease at diagnosis. Shotgun metagenomic microbiome analysis revealed 4 species that were significantly expanded with hyperglycemia/hyperinsulinemia, and 2 species that were differentially more prevalent in prediabetic/diabetic PLWH. Collectively, we uncover multiple potential host and microbiome predictors of altered glycemic status in PLWH, while demonstrating that FBG and HbA1C likely suffice for diabetes screening. These potential diabetic predictors merit future prospective validation.

Keyword(s): HIV/AIDS ; Prediction and Prevention ; Type 2 Diabetes ; microbiome ; prediabetes

Note: 2024 Aug 16;230(2):411-420

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Contributing Institute(s):

1. Mikrobiom und Krebs (F220)
2. NWG Epithel-Mikrobiom-Interaktionen (D480)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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