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@ARTICLE{Shaikh:289786,
      author       = {S. Shaikh and S. Escribano-Rodriguez and R. Radogna and L.
                      Kelleter$^*$ and C. Godden and M. Warren and D. Attree and
                      R. Saakyan and L. Mortimer and P. Corlett and A. Warry and
                      A. Gosling and C. Baker and A. Poynter and A. Kacperek and
                      S. Jolly},
      title        = {{S}pread-out {B}ragg peak measurements using a compact
                      quality assurance range calorimeter at the {C}latterbridge
                      {C}ancer {C}entre.},
      journal      = {Physics in medicine and biology},
      volume       = {69},
      number       = {11},
      issn         = {0031-9155},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2024-00865},
      pages        = {115015},
      year         = {2024},
      abstract     = {The superior dose conformity provided by proton therapy
                      relative to conventional X-ray radiotherapy necessitates
                      more rigorous Quality Assurance (QA) procedures to ensure
                      optimal patient safety. Practically however,
                      time-constraints prevent comprehensive measurements to be
                      made of the proton range in water: a key parameter in
                      ensuring accurate treatment delivery.A novel
                      scintillator-based device for fast, accurate
                      water-equivalent proton range QA measurements for ocular
                      proton therapy is presented. Experiments were conducted
                      using a compact detector prototype, the Quality Assurance
                      Range Calorimeter (QuARC), at the Clatterbridge Cancer
                      Centre (CCC) in Wirral, UK for the measurement of pristine
                      and spread-out Bragg peaks (SOBPs). The QuARC uses a series
                      of 14 optically-isolated 100 x 100 x 2.85 mm polystyrene
                      scintillator sheets, read out by a series of photodiodes.
                      The detector system is housed in a custom 3D-printed
                      enclosure mounted directly to the nozzle and a numerical
                      model was used to fit measured depth-light curves and
                      correct for scintillator light quenching.Measurements of the
                      pristine 60 MeV proton Bragg curve found the QuARC able to
                      measure proton ranges accurate to 0.2 mm and reduced QA
                      measurement times from several minutes down to a few
                      seconds. A new framework of the quenching model was deployed
                      to successfully fit depth-light curves of SOBPs with similar
                      range accuracy.The speed, range accuracy and simplicity of
                      the QuARC make the device a promising candidate for ocular
                      proton range QA. Further work to investigate the performance
                      of SOBP fitting at higher energies/greater depths is
                      warranted.},
      keywords     = {plastic scintillator (Other) / proton therapy (Other) /
                      quality assurance (Other) / spread out Bragg peak (Other)},
      cin          = {E040},
      ddc          = {530},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38657625},
      doi          = {10.1088/1361-6560/ad42fd},
      url          = {https://inrepo02.dkfz.de/record/289786},
}