Journal Article

DKFZ-2024-00865

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Spread-out Bragg peak measurements using a compact quality assurance range calorimeter at the Clatterbridge Cancer Centre.

Shaikh, S. ; Escribano-Rodriguez, S. ; Radogna, R. ; Kelleter, L.DKFZ* ; Godden, C. ; Warren, M. ; Attree, D. ; Saakyan, R. ; Mortimer, L. ; Corlett, P. ; Warry, A. ; Gosling, A. ; Baker, C. ; Poynter, A. ; Kacperek, A. ; Jolly, S.

2024
IOP Publ. Bristol

Abstract: The superior dose conformity provided by proton therapy relative to conventional X-ray radiotherapy necessitates more rigorous Quality Assurance (QA) procedures to ensure optimal patient safety. Practically however, time-constraints prevent comprehensive measurements to be made of the proton range in water: a key parameter in ensuring accurate treatment delivery.A novel scintillator-based device for fast, accurate water-equivalent proton range QA measurements for ocular proton therapy is presented. Experiments were conducted using a compact detector prototype, the Quality Assurance Range Calorimeter (QuARC), at the Clatterbridge Cancer Centre (CCC) in Wirral, UK for the measurement of pristine and spread-out Bragg peaks (SOBPs). The QuARC uses a series of 14 optically-isolated 100 x 100 x 2.85 mm polystyrene scintillator sheets, read out by a series of photodiodes. The detector system is housed in a custom 3D-printed enclosure mounted directly to the nozzle and a numerical model was used to fit measured depth-light curves and correct for scintillator light quenching.Measurements of the pristine 60 MeV proton Bragg curve found the QuARC able to measure proton ranges accurate to 0.2 mm and reduced QA measurement times from several minutes down to a few seconds. A new framework of the quenching model was deployed to successfully fit depth-light curves of SOBPs with similar range accuracy.The speed, range accuracy and simplicity of the QuARC make the device a promising candidate for ocular proton range QA. Further work to investigate the performance of SOBP fitting at higher energies/greater depths is warranted.

Keyword(s): plastic scintillator ; proton therapy ; quality assurance ; spread out Bragg peak

---

Contributing Institute(s):

1. E040 Med. Physik in der Strahlentherapie (E040)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2024

---

Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---