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| 100 | 1 | _ | |a Glowa, Christin |0 P:(DE-He78)06ec1253cfc102aebeeb536a65133370 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Relative biological effectiveness of oxygen ion beams in the rat spinal cord: Dependence on linear energy transfer and dose and comparison with model predictions. |
| 260 | _ | _ | |a Amsterdam [u. a.] |c 2024 |b Elsevier Science |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Ion beams exhibit an increased relative biological effectiveness (RBE) with respect to photons. This study determined the RBE of oxygen ion beams as a function of linear energy transfer (LET) and dose in the rat spinal cord.The spinal cord of rats was irradiated at four different positions of a 6 cm spread-out Bragg-peak (LET: 26, 66, 98 and 141 keV/µm) using increasing levels of single and split oxygen ion doses. Dose-response curves were established for the endpoint paresis grade II and based on ED50 (dose at 50 % effect probability), the RBE was determined and compared to model predictions.When LET increased from 26 to 98 keV/µm, ED50 decreased from 17.2 ± 0.3 Gy to 13.5 ± 0.4 Gy for single and from 21.7 ± 0.4 Gy to 15.5 ± 0.5 Gy for split doses, however, at 141 keV/µm, ED50 rose again to 15.8 ± 0.4 Gy and 17.2 ± 0.4 Gy, respectively. As a result, the RBE increased from 1.43 ± 0.05 to 1.82 ± 0.08 (single dose) and from 1.58 ± 0.04 to 2.21 ± 0.08 (split dose), respectively, before declining again to 1.56 ± 0.06 for single and 1.99 ± 0.06 for split doses at the highest LET. Deviations from RBE-predictions were model-dependent.This study established first RBE data for the late reacting central nervous system after single and split doses of oxygen ions. The data was used to validate the RBE-dependence on LET and dose of three RBE-models. This study extends the existing data base for protons, helium and carbon ions and provides important information for future patient treatments with oxygen ions. |
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| 650 | _ | 7 | |a Late normal tissue effects |2 Other |
| 650 | _ | 7 | |a Linear energy transfer (LET) |2 Other |
| 650 | _ | 7 | |a Local effect model (LEM) |2 Other |
| 650 | _ | 7 | |a Modified microdosimetric kinetic model (mMKM) |2 Other |
| 650 | _ | 7 | |a Myelopathy |2 Other |
| 650 | _ | 7 | |a Oxygen ion radiotherapy |2 Other |
| 650 | _ | 7 | |a Rat spinal cord |2 Other |
| 650 | _ | 7 | |a Relative biological effectiveness (RBE) |2 Other |
| 700 | 1 | _ | |a Saager, Maria |0 P:(DE-He78)132c557ecfe3de184432e5ac8a9c7308 |b 1 |
| 700 | 1 | _ | |a Hintz, Lisa |0 P:(DE-He78)6e765266561c869659589500555d49c4 |b 2 |
| 700 | 1 | _ | |a Euler-Lange, Rosemarie |0 P:(DE-He78)f628d9e6d7787963743903d31510bbad |b 3 |u dkfz |
| 700 | 1 | _ | |a Peschke, Peter |0 P:(DE-He78)1bf5666dbe17c0fd5e81301c52f6347a |b 4 |
| 700 | 1 | _ | |a Brons, Stephan |b 5 |
| 700 | 1 | _ | |a Scholz, Michael |b 6 |
| 700 | 1 | _ | |a Mein, Stewart |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Mairani, Andrea |0 P:(DE-He78)8d6c2aceda79e88defe1e8c0fcc39d59 |b 8 |u dkfz |
| 700 | 1 | _ | |a Karger, Christian |0 P:(DE-He78)b43076fb0a30230e4323887c0c980046 |b 9 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.phro.2024.100581 |g Vol. 30, p. 100581 - |0 PERI:(DE-600)2963795-8 |p 100581 |t Physics & Imaging in Radiation Oncology |v 30 |y 2024 |x 2405-6316 |
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