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@ARTICLE{Aslam:290204,
      author       = {A. Aslam and F. Masood and K. Perveen and M. Berger$^*$ and
                      A. Pervaiz and M. Zepp$^*$ and K. D. Klika$^*$ and T. Yasin
                      and A. Hameed},
      title        = {{P}reparation, characterization and evaluation of
                      {HP}β{CD}-{PTX}/{PHB} nanoparticles for p{H}-responsive,
                      cytotoxic and apoptotic properties.},
      journal      = {International journal of biological macromolecules},
      volume       = {270},
      number       = {Part 2},
      issn         = {0141-8130},
      address      = {New York, NY [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2024-01037},
      pages        = {132268},
      year         = {2024},
      note         = {Volume 270, Part 2, June 2024, 132268},
      abstract     = {Paclitaxel (PTX) is a potent anticancer drug. However, PTX
                      exhibits extremely poor solubility in aqueous solution along
                      with severe side effects. Therefore, in this study, an
                      inclusion complex was prepared between PTX and
                      hydroxypropyl-β-cyclodextrin (HPβCD) by solvent
                      evaporation to enhance the drug's solubility. The HPβCD-PTX
                      inclusion complex was then encapsulated in
                      poly-3-hydroxybutyrate (PHB) to fabricate drug-loaded
                      nanoparticles (HPβCD-PTX/PHB NPs) by nanoprecipitation. The
                      HPβCD-PTX/PHB NPs depicted a higher release of PTX at pH
                      5.5 thus demonstrating a pH-dependent release profile. The
                      cytotoxic properties of HPβCD-PTX/PHB NPs were tested
                      against MCF-7, MDA-MB-231 and SW-620 cell lines. The
                      cytotoxic potential of HPβCD-PTX/PHB NPs was 2.59-fold
                      improved in MCF-7 cells in comparison to free PTX.
                      Additionally, the HPβCD-PTX/PHB NPs improved the
                      antimitotic (1.68-fold) and apoptotic (8.45-fold) effects of
                      PTX in MCF-7 cells in comparison to PTX alone. In summary,
                      these pH-responsive nanoparticles could be prospective
                      carriers for enhancing the cytotoxic properties of PTX for
                      the treatment of breast cancer.},
      keywords     = {HPβCD-drug inclusion complex (Other) / Nano-system (Other)
                      / PHB (Other) / Paclitaxel (Other)},
      cin          = {G401 / A390},
      ddc          = {570},
      cid          = {I:(DE-He78)G401-20160331 / I:(DE-He78)A390-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38734336},
      doi          = {10.1016/j.ijbiomac.2024.132268},
      url          = {https://inrepo02.dkfz.de/record/290204},
}