%0 Journal Article
%A Zhang, Ke
%A Triphan, Simon M F
%A Wielpütz, Mark O
%A Ziener, Christian H
%A Ladd, Mark E
%A Schlemmer, Heinz-Peter
%A Kauczor, Hans-Ulrich
%A Sedlaczek, Oliver
%A Kurz, Felix Tobias
%T Navigator-based motion compensation for liver BOLD measurement with five-echo SAGE EPI and breath-hold task.
%J NMR in biomedicine
%V 37
%N 10
%@ 0952-3480
%C New York, NY
%I Wiley
%M DKFZ-2024-01092
%P e5173
%D 2024
%Z #LA:E010# / 2024 Oct;37(10):e5173
%X The purpose of this work is to apply multi-echo spin- and gradient-echo (SAGE) echo-planar imaging (EPI) combined with a navigator-based (NAV) prospective motion compensation method for a quantitative liver blood oxygen level dependent (BOLD) measurement with a breath-hold (BH) task.A five-echo SAGE sequence was developed to quantitatively measure T2 and T2* to depict function with sufficient signal-to-noise ratio, spatial resolution and sensitivity to BOLD changes induced by the BH task. To account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI-based readouts, navigator acquisition and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. Six healthy volunteers and three patients with liver carcinoma were included in this study. Quantitative T2 and T2* were calculated at each time point of the BH task. Parameters of t value from first-level analysis using a general linear model and hepatovascular reactivity (HVR) of Echo1, T2 and T2* were calculated.The motion caused by respiratory activity was successfully compensated using the navigator signal. The average changes of T2 and T2* during breath-hold were about 1
%K hepatovascular reactivity (Other)
%K navigator‐based slice tracking (Other)
%K prospective motion compensation (Other)
%K quantitative liver BOLD (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38783837
%R 10.1002/nbm.5173
%U https://inrepo02.dkfz.de/record/290379