Journal Article

DKFZ-2024-01092

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Navigator-based motion compensation for liver BOLD measurement with five-echo SAGE EPI and breath-hold task.

Zhang, K. ; Triphan, S. M. F. ; Wielpütz, M. O. ; Ziener, C. H.DKFZ* ; Ladd, M. E.DKFZ* ; Schlemmer, H.-P.DKFZ* ; Kauczor, H.-U. ; Sedlaczek, O.DKFZ* ; Kurz, F. T. (Last author)DKFZ*

2024
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/nbm.5173

Abstract: The purpose of this work is to apply multi-echo spin- and gradient-echo (SAGE) echo-planar imaging (EPI) combined with a navigator-based (NAV) prospective motion compensation method for a quantitative liver blood oxygen level dependent (BOLD) measurement with a breath-hold (BH) task.A five-echo SAGE sequence was developed to quantitatively measure T2 and T2* to depict function with sufficient signal-to-noise ratio, spatial resolution and sensitivity to BOLD changes induced by the BH task. To account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI-based readouts, navigator acquisition and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. Six healthy volunteers and three patients with liver carcinoma were included in this study. Quantitative T2 and T2* were calculated at each time point of the BH task. Parameters of t value from first-level analysis using a general linear model and hepatovascular reactivity (HVR) of Echo1, T2 and T2* were calculated.The motion caused by respiratory activity was successfully compensated using the navigator signal. The average changes of T2 and T2* during breath-hold were about 1% and 0.7%, respectively. With the help of NAV prospective motion compensation whole liver t values could be obtained without motion artifacts. The quantified liver T2 (34.7 ± 0.7 ms) and T2* (29 ± 1.2 ms) values agreed with values from literature. In healthy volunteers, the distribution of statistical t value and HVR was homogeneous throughout the whole liver. In patients with liver carcinoma, the distribution of t value and HVR was inhomogeneous due to metastases or therapy.This study demonstrates the feasibility of using a NAV prospective motion compensation technique in conjunction with five-echo SAGE EPI for the quantitative measurement of liver BOLD with a BH task.

Keyword(s): hepatovascular reactivity ; navigator‐based slice tracking ; prospective motion compensation ; quantitative liver BOLD

Note: #LA:E010# / 2024 Oct;37(10):e5173

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Contributing Institute(s):

1. E010 Radiologie (E010)
2. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2024

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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