TY  - JOUR
AU  - Zhang, Ke
AU  - Triphan, Simon M F
AU  - Wielpütz, Mark O
AU  - Ziener, Christian H
AU  - Ladd, Mark E
AU  - Schlemmer, Heinz-Peter
AU  - Kauczor, Hans-Ulrich
AU  - Sedlaczek, Oliver
AU  - Kurz, Felix Tobias
TI  - Navigator-based motion compensation for liver BOLD measurement with five-echo SAGE EPI and breath-hold task.
JO  - NMR in biomedicine
VL  - 37
IS  - 10
SN  - 0952-3480
CY  - New York, NY
PB  - Wiley
M1  - DKFZ-2024-01092
SP  - e5173
PY  - 2024
N1  - #LA:E010# / 2024 Oct;37(10):e5173
AB  - The purpose of this work is to apply multi-echo spin- and gradient-echo (SAGE) echo-planar imaging (EPI) combined with a navigator-based (NAV) prospective motion compensation method for a quantitative liver blood oxygen level dependent (BOLD) measurement with a breath-hold (BH) task.A five-echo SAGE sequence was developed to quantitatively measure T2 and T2* to depict function with sufficient signal-to-noise ratio, spatial resolution and sensitivity to BOLD changes induced by the BH task. To account for respiratory motion, a navigator was employed in the form of a single gradient-echo projection readout, located at the diaphragm along the inferior-superior direction. Prior to each transverse imaging slice of the spin-echo EPI-based readouts, navigator acquisition and fat suppression were incorporated. Motion data was obtained from the navigator and transmitted back to the sequence, allowing real-time adjustments to slice positioning. Six healthy volunteers and three patients with liver carcinoma were included in this study. Quantitative T2 and T2* were calculated at each time point of the BH task. Parameters of t value from first-level analysis using a general linear model and hepatovascular reactivity (HVR) of Echo1, T2 and T2* were calculated.The motion caused by respiratory activity was successfully compensated using the navigator signal. The average changes of T2 and T2* during breath-hold were about 1
KW  - hepatovascular reactivity (Other)
KW  - navigator‐based slice tracking (Other)
KW  - prospective motion compensation (Other)
KW  - quantitative liver BOLD (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38783837
DO  - DOI:10.1002/nbm.5173
UR  - https://inrepo02.dkfz.de/record/290379
ER  -