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@ARTICLE{Rosenkranz:290512,
      author       = {M. Rosenkranz and I. N. Nkumama$^*$ and R. Ogwang and S.
                      Kraker and M. Blickling and K. Mwai and D. Odera and J. Tuju
                      and K. Fürle and R. Frank and E. Chepsat and M. C. Kapulu
                      and C.-S. Study Team and F. H. Osier},
      title        = {{F}ull-length {MSP}1 is a major target of protective
                      immunity after controlled human malaria infection.},
      journal      = {Life science alliance},
      volume       = {7},
      number       = {8},
      issn         = {2575-1077},
      address      = {Heidelberg},
      publisher    = {EMBO Press},
      reportid     = {DKFZ-2024-01139},
      pages        = {e202301910 -},
      year         = {2024},
      note         = {B Cell Immunology, German Cancer Research Center},
      abstract     = {The merozoite surface protein 1 (MSP1) is the most abundant
                      protein on the surface of the invasive merozoite stages of
                      Plasmodium falciparum and has long been considered a key
                      target of protective immunity. We used samples from a single
                      controlled human malaria challenge study to test whether the
                      full-length version of MSP1 (MSP1FL) induced antibodies that
                      mediated Fc-IgG functional activity in five independent
                      assays. We found that anti-MSP1FL antibodies induced
                      complement fixation via C1q, monocyte-mediated phagocytosis,
                      neutrophil respiratory burst, and natural killer cell
                      degranulation as well as IFNγ production. Activity in each
                      of these assays was strongly associated with protection. The
                      breadth of MSP1-specific Fc-mediated effector functions was
                      more strongly associated with protection than the individual
                      measures and closely mirrored what we have previously
                      reported using the same assays against merozoites. Our
                      findings suggest that MSP1FL is an important target of
                      functional antibodies that contribute to a protective immune
                      response against malaria.},
      keywords     = {Humans / Merozoite Surface Protein 1: immunology / Malaria,
                      Falciparum: immunology / Malaria, Falciparum: parasitology /
                      Plasmodium falciparum: immunology / Antibodies, Protozoan:
                      immunology / Phagocytosis: immunology / Immunoglobulin G:
                      immunology / Killer Cells, Natural: immunology / Killer
                      Cells, Natural: metabolism / Interferon-gamma: metabolism /
                      Interferon-gamma: immunology / Female / Merozoites:
                      immunology / Neutrophils: immunology / Neutrophils:
                      metabolism / Merozoite Surface Protein 1 (NLM Chemicals) /
                      Antibodies, Protozoan (NLM Chemicals) / Immunoglobulin G
                      (NLM Chemicals) / Interferon-gamma (NLM Chemicals)},
      cin          = {D130},
      ddc          = {570},
      cid          = {I:(DE-He78)D130-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38803222},
      doi          = {10.26508/lsa.202301910},
      url          = {https://inrepo02.dkfz.de/record/290512},
}