Journal Article

DKFZ-2024-01139

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Full-length MSP1 is a major target of protective immunity after controlled human malaria infection.

Rosenkranz, M. ; Nkumama, I. N.DKFZ* ; Ogwang, R. ; Kraker, S. ; Blickling, M. ; Mwai, K. ; Odera, D. ; Tuju, J. ; Fürle, K. ; Frank, R. ; Chepsat, E. ; Kapulu, M. C. ; Study Team, C.-S. ; Osier, F. H.

2024
EMBO Press Heidelberg

This record in other databases:  

Please use a persistent id in citations: doi:10.26508/lsa.202301910

Abstract: The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the invasive merozoite stages of Plasmodium falciparum and has long been considered a key target of protective immunity. We used samples from a single controlled human malaria challenge study to test whether the full-length version of MSP1 (MSP1FL) induced antibodies that mediated Fc-IgG functional activity in five independent assays. We found that anti-MSP1FL antibodies induced complement fixation via C1q, monocyte-mediated phagocytosis, neutrophil respiratory burst, and natural killer cell degranulation as well as IFNγ production. Activity in each of these assays was strongly associated with protection. The breadth of MSP1-specific Fc-mediated effector functions was more strongly associated with protection than the individual measures and closely mirrored what we have previously reported using the same assays against merozoites. Our findings suggest that MSP1FL is an important target of functional antibodies that contribute to a protective immune response against malaria.

Keyword(s): Humans (MeSH) ; Merozoite Surface Protein 1: immunology (MeSH) ; Malaria, Falciparum: immunology (MeSH) ; Malaria, Falciparum: parasitology (MeSH) ; Plasmodium falciparum: immunology (MeSH) ; Antibodies, Protozoan: immunology (MeSH) ; Phagocytosis: immunology (MeSH) ; Immunoglobulin G: immunology (MeSH) ; Killer Cells, Natural: immunology (MeSH) ; Killer Cells, Natural: metabolism (MeSH) ; Interferon-gamma: metabolism (MeSH) ; Interferon-gamma: immunology (MeSH) ; Female (MeSH) ; Merozoites: immunology (MeSH) ; Neutrophils: immunology (MeSH) ; Neutrophils: metabolism (MeSH) ; Merozoite Surface Protein 1 ; Antibodies, Protozoan ; Immunoglobulin G ; Interferon-gamma

Note: B Cell Immunology, German Cancer Research Center

---

Contributing Institute(s):

1. B-Zell-Immunologie (D130)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

---

Database coverage:
; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---