TY  - JOUR
AU  - Grut, Viktor
AU  - Biström, Martin
AU  - Salzer, Jonatan
AU  - Stridh, Pernilla
AU  - Jons, Daniel
AU  - Gustafsson, Rasmus
AU  - Huang, Jesse
AU  - Bergström, Tomas
AU  - Kockum, Ingrid
AU  - Waterboer, Tim
AU  - Olsson, Tomas
AU  - Sundström, Peter
TI  - Interactions between High Seroreactivity to Human Herpes Virus 6A and Epstein-Barr Virus in MS Development: A Presymptomatic Case-Control Study.
JO  - Annals of neurology
VL  - 96
IS  - 2
SN  - 0364-5134
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DKFZ-2024-01250
SP  - 302-305
PY  - 2024
N1  - 2024 Aug;96(2):302-305
AB  - Synergistic interactions between human herpesvirus 6A (HHV-6A) and Epstein-Barr virus (EBV) are hypothesized in the etiopathogenesis of multiple sclerosis (MS). This study investigated if HHV-6A and EBV seroreactivities interact regarding the risk of developing MS. Antibodies against viral antigens were analyzed in biobank samples from 670 individuals who later developed MS and matched controls. Additive interactions were analyzed. A significant interaction between HHV-6A and EBNA-1 seroreactivities was observed in study participants above the median age of 24.9 years (attributable proportion due to interaction = 0.45). This finding supports the hypothesis that HHV-6A and EBV infections interact in MS development. ANN NEUROL 2024.
LB  - PUB:(DE-HGF)16
C6  - pmid:38860471
DO  - DOI:10.1002/ana.27009
UR  - https://inrepo02.dkfz.de/record/290916
ER  -