Journal Article

DKFZ-2024-01250

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interactions between High Seroreactivity to Human Herpes Virus 6A and Epstein-Barr Virus in MS Development: A Presymptomatic Case-Control Study.

Grut, V. ; Biström, M. ; Salzer, J. ; Stridh, P. ; Jons, D. ; Gustafsson, R. ; Huang, J. ; Bergström, T. ; Kockum, I. ; Waterboer, T.DKFZ* ; Olsson, T. ; Sundström, P.

2024
Wiley-Blackwell Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/ana.27009

Abstract: Synergistic interactions between human herpesvirus 6A (HHV-6A) and Epstein-Barr virus (EBV) are hypothesized in the etiopathogenesis of multiple sclerosis (MS). This study investigated if HHV-6A and EBV seroreactivities interact regarding the risk of developing MS. Antibodies against viral antigens were analyzed in biobank samples from 670 individuals who later developed MS and matched controls. Additive interactions were analyzed. A significant interaction between HHV-6A and EBNA-1 seroreactivities was observed in study participants above the median age of 24.9 years (attributable proportion due to interaction = 0.45). This finding supports the hypothesis that HHV-6A and EBV infections interact in MS development. ANN NEUROL 2024.

Note: 2024 Aug;96(2):302-305

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Contributing Institute(s):

1. Infektionen und Krebs-Epidemiologie (D320)
2. Infektionen und Krebs-Epidemiologie (F020)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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