TY  - JOUR
AU  - Veal, Elizabeth A
AU  - Kritsiligkou, Paraskevi
TI  - How are hydrogen peroxide messages relayed to affect cell signalling?
JO  - Current opinion in chemical biology
VL  - 81
SN  - 1367-5931
CY  - London
PB  - Current Biology Ltd.
M1  - DKFZ-2024-01416
SP  - 102496
PY  - 2024
N1  - #LA:A160# / DKFZ-ZMBH Alliance
AB  - H2O2 signals trigger adaptive responses affecting cell division, differentiation, migration, and survival. These signals are transduced by selective oxidation of cysteines on specific target proteins, with redox-sensitive cysteines now identified in many proteins, including both kinases and phosphatases. Assessing the contribution of these oxidation events to cell signalling presents several challenges including understanding how and when the selective oxidation of specific proteins takes place in vivo. In recent years, a combination of biochemical, structural, genetic, and computational approaches in fungi, plants, and animals have revealed different ways in which thiol peroxidases (peroxiredoxins) are bypassed or utilised in relaying these signals. Together, these mechanisms provide a conceptual framework for selectively oxidising proteins that will further advance understanding of how redox modifications contribute to health and disease.
LB  - PUB:(DE-HGF)16
C6  - pmid:38959751
DO  - DOI:10.1016/j.cbpa.2024.102496
UR  - https://inrepo02.dkfz.de/record/291453
ER  -