Journal Article (Review Article)

DKFZ-2024-01416

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png How are hydrogen peroxide messages relayed to affect cell signalling?

Veal, E. A. ; Kritsiligkou, P. (Last author)DKFZ*

2024
Current Biology Ltd. London

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Please use a persistent id in citations: doi:10.1016/j.cbpa.2024.102496

Abstract: H2O2 signals trigger adaptive responses affecting cell division, differentiation, migration, and survival. These signals are transduced by selective oxidation of cysteines on specific target proteins, with redox-sensitive cysteines now identified in many proteins, including both kinases and phosphatases. Assessing the contribution of these oxidation events to cell signalling presents several challenges including understanding how and when the selective oxidation of specific proteins takes place in vivo. In recent years, a combination of biochemical, structural, genetic, and computational approaches in fungi, plants, and animals have revealed different ways in which thiol peroxidases (peroxiredoxins) are bypassed or utilised in relaying these signals. Together, these mechanisms provide a conceptual framework for selectively oxidising proteins that will further advance understanding of how redox modifications contribute to health and disease.

Note: #LA:A160# / DKFZ-ZMBH Alliance

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Contributing Institute(s):

1. A160 Redoxregulation (A160)

Research Program(s):

1. 311 - Zellbiologie und Tumorbiologie (POF4-311) (POF4-311)

Appears in the scientific report 2024

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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