%0 Journal Article
%A Tkotz, Katharina
%A Zeiger, Paula
%A Hanspach, Jannis
%A Mathy, Claudius S
%A Laun, Frederik B
%A Uder, Michael
%A Nagel, Armin M
%A Gast, Lena V
%T Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.
%J Magnetic resonance materials in physics, biology and medicine
%V 37
%@ 0968-5243
%C Heidelberg
%I Springer
%M DKFZ-2024-01603
%P 969–981
%D 2024
%Z Volume 37, pages 969–981, (2024)
%X To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B0 map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement.PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.
%K 7 Tesla (Other)
%K Dixon MRI (Other)
%K Fat–water separation (FWS) (Other)
%K Proton density fat fraction (PDFF) (Other)
%K Skeletal muscle tissue (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39105951
%R 10.1007/s10334-024-01195-2
%U https://inrepo02.dkfz.de/record/292104