Journal Article

DKFZ-2024-01603

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.

Tkotz, K. ; Zeiger, P. ; Hanspach, J. ; Mathy, C. S. ; Laun, F. B. ; Uder, M. ; Nagel, A. M.DKFZ* ; Gast, L. V.

2024
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s10334-024-01195-2

Abstract: To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B0 map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement.PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.

Keyword(s): 7 Tesla ; Dixon MRI ; Fat–water separation (FWS) ; Proton density fat fraction (PDFF) ; Skeletal muscle tissue

Note: Volume 37, pages 969–981, (2024)

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Contributing Institute(s):

1. E020 Med. Physik in der Radiologie (E020)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2024

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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