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000292104 041__ $$aEnglish
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000292104 1001_ $$00000-0002-0847-2729$$aTkotz, Katharina$$b0
000292104 245__ $$aParameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.
000292104 260__ $$aHeidelberg$$bSpringer$$c2024
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000292104 500__ $$aVolume 37, pages 969–981, (2024)
000292104 520__ $$aTo establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B0 map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement.PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.
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000292104 650_7 $$2Other$$a7 Tesla
000292104 650_7 $$2Other$$aDixon MRI
000292104 650_7 $$2Other$$aFat–water separation (FWS)
000292104 650_7 $$2Other$$aProton density fat fraction (PDFF)
000292104 650_7 $$2Other$$aSkeletal muscle tissue
000292104 7001_ $$aZeiger, Paula$$b1
000292104 7001_ $$aHanspach, Jannis$$b2
000292104 7001_ $$aMathy, Claudius S$$b3
000292104 7001_ $$aLaun, Frederik B$$b4
000292104 7001_ $$aUder, Michael$$b5
000292104 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b6$$udkfz
000292104 7001_ $$aGast, Lena V$$b7
000292104 773__ $$0PERI:(DE-600)1502491-X$$a10.1007/s10334-024-01195-2$$p969–981$$tMagnetic resonance materials in physics, biology and medicine$$v37$$x0968-5243$$y2024
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