TY  - JOUR
AU  - Tkotz, Katharina
AU  - Zeiger, Paula
AU  - Hanspach, Jannis
AU  - Mathy, Claudius S
AU  - Laun, Frederik B
AU  - Uder, Michael
AU  - Nagel, Armin M
AU  - Gast, Lena V
TI  - Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.
JO  - Magnetic resonance materials in physics, biology and medicine
VL  - 37
SN  - 0968-5243
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2024-01603
SP  - 969–981
PY  - 2024
N1  - Volume 37, pages 969–981, (2024)
AB  - To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B0 map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement.PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.
KW  - 7 Tesla (Other)
KW  - Dixon MRI (Other)
KW  - Fat–water separation (FWS) (Other)
KW  - Proton density fat fraction (PDFF) (Other)
KW  - Skeletal muscle tissue (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39105951
DO  - DOI:10.1007/s10334-024-01195-2
UR  - https://inrepo02.dkfz.de/record/292104
ER  -