% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Tkotz:292104,
      author       = {K. Tkotz and P. Zeiger and J. Hanspach and C. S. Mathy and
                      F. B. Laun and M. Uder and A. M. Nagel$^*$ and L. V. Gast},
      title        = {{P}arameter optimization for proton density fat fraction
                      quantification in skeletal muscle tissue at 7 {T}.},
      journal      = {Magnetic resonance materials in physics, biology and
                      medicine},
      volume       = {37},
      issn         = {0968-5243},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2024-01603},
      pages        = {969–981},
      year         = {2024},
      note         = {Volume 37, pages 969–981, (2024)},
      abstract     = {To establish an image acquisition and post-processing
                      workflow for the determination of the proton density fat
                      fraction (PDFF) in calf muscle tissue at 7 T.Echo times
                      (TEs) of the applied vendor-provided multi-echo gradient
                      echo sequence were optimized based on simulations of the
                      effective number of signal averages (NSA*). The resulting
                      parameters were validated by measurements in phantom and in
                      healthy calf muscle tissue (n = 12). Additionally, methods
                      to reduce phase errors arising at 7 T were evaluated.
                      Finally, PDFF values measured at 7 T in calf muscle tissue
                      of healthy subjects (n = 9) and patients with fatty
                      replacement of muscle tissue (n = 3) were compared to 3 T
                      results.Simulations, phantom and in vivo measurements showed
                      the importance of using optimized TEs for the fat-water
                      separation at 7 T. Fat-water swaps could be mitigated using
                      a phase demodulation with an additional B0 map, or by
                      shifting the TEs to longer values. Muscular PDFF values
                      measured at 7 T were comparable to measurements at 3 T in
                      both healthy subjects and patients with increased fatty
                      replacement.PDFF determination in calf muscle tissue is
                      feasible at 7 T using a chemical shift-based approach with
                      optimized acquisition and post-processing parameters.},
      keywords     = {7 Tesla (Other) / Dixon MRI (Other) / Fat–water
                      separation (FWS) (Other) / Proton density fat fraction
                      (PDFF) (Other) / Skeletal muscle tissue (Other)},
      cin          = {E020},
      ddc          = {530},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39105951},
      doi          = {10.1007/s10334-024-01195-2},
      url          = {https://inrepo02.dkfz.de/record/292104},
}