Home > Publications database > Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T. > print |
001 | 292104 | ||
005 | 20250416144726.0 | ||
024 | 7 | _ | |a 10.1007/s10334-024-01195-2 |2 doi |
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024 | 7 | _ | |a 0968-5243 |2 ISSN |
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037 | _ | _ | |a DKFZ-2024-01603 |
041 | _ | _ | |a English |
082 | _ | _ | |a 530 |
100 | 1 | _ | |a Tkotz, Katharina |0 0000-0002-0847-2729 |b 0 |
245 | _ | _ | |a Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T. |
260 | _ | _ | |a Heidelberg |c 2024 |b Springer |
336 | 7 | _ | |a article |2 DRIVER |
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336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1732200012_5932 |2 PUB:(DE-HGF) |
336 | 7 | _ | |a ARTICLE |2 BibTeX |
336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
500 | _ | _ | |a Volume 37, pages 969–981, (2024) |
520 | _ | _ | |a To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B0 map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement.PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters. |
536 | _ | _ | |a 315 - Bildgebung und Radioonkologie (POF4-315) |0 G:(DE-HGF)POF4-315 |c POF4-315 |f POF IV |x 0 |
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650 | _ | 7 | |a 7 Tesla |2 Other |
650 | _ | 7 | |a Dixon MRI |2 Other |
650 | _ | 7 | |a Fat–water separation (FWS) |2 Other |
650 | _ | 7 | |a Proton density fat fraction (PDFF) |2 Other |
650 | _ | 7 | |a Skeletal muscle tissue |2 Other |
700 | 1 | _ | |a Zeiger, Paula |b 1 |
700 | 1 | _ | |a Hanspach, Jannis |b 2 |
700 | 1 | _ | |a Mathy, Claudius S |b 3 |
700 | 1 | _ | |a Laun, Frederik B |b 4 |
700 | 1 | _ | |a Uder, Michael |b 5 |
700 | 1 | _ | |a Nagel, Armin M |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 6 |u dkfz |
700 | 1 | _ | |a Gast, Lena V |b 7 |
773 | _ | _ | |a 10.1007/s10334-024-01195-2 |0 PERI:(DE-600)1502491-X |p 969–981 |t Magnetic resonance materials in physics, biology and medicine |v 37 |y 2024 |x 0968-5243 |
856 | 4 | _ | |u https://inrepo02.dkfz.de/record/292104/files/s10334-024-01195-2.pdf |
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