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005     20250416144726.0
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037 _ _ |a DKFZ-2024-01603
041 _ _ |a English
082 _ _ |a 530
100 1 _ |a Tkotz, Katharina
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245 _ _ |a Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.
260 _ _ |a Heidelberg
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500 _ _ |a Volume 37, pages 969–981, (2024)
520 _ _ |a To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.Simulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B0 map, or by shifting the TEs to longer values. Muscular PDFF values measured at 7 T were comparable to measurements at 3 T in both healthy subjects and patients with increased fatty replacement.PDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.
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650 _ 7 |a 7 Tesla
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650 _ 7 |a Dixon MRI
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650 _ 7 |a Fat–water separation (FWS)
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650 _ 7 |a Proton density fat fraction (PDFF)
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650 _ 7 |a Skeletal muscle tissue
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700 1 _ |a Zeiger, Paula
|b 1
700 1 _ |a Hanspach, Jannis
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700 1 _ |a Mathy, Claudius S
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700 1 _ |a Laun, Frederik B
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700 1 _ |a Uder, Michael
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700 1 _ |a Nagel, Armin M
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700 1 _ |a Gast, Lena V
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773 _ _ |a 10.1007/s10334-024-01195-2
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|t Magnetic resonance materials in physics, biology and medicine
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856 4 _ |u https://inrepo02.dkfz.de/record/292104/files/s10334-024-01195-2.pdf
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