%0 Journal Article
%A Gray, Penelope
%A Mariz, Filipe Colaço
%A Eklund, Carina
%A Eriksson, Tiina
%A Faust, Helena
%A Kann, Hanna
%A Müller, Martin
%A Paavonen, Jorma
%A Pimenoff, Ville N
%A Sehr, Peter
%A Surcel, Heljä-Marja
%A Dillner, Joakim
%A Waterboer, Tim
%A Lehtinen, Matti
%T Lack of detectable HPV18 antibodies in 14
%J npj vaccines
%V 9
%N 1
%@ 2059-0105
%C [London]
%I Nature Publishing Group
%M DKFZ-2024-01659
%P 146
%D 2024
%Z #EA:D335#
%X Although HPV vaccines are highly efficacious, a notable proportion of quadrivalent vaccinees are HPV18 seronegative post-vaccination. We have investigated this findings' validity by comparing vaccine-induced antibody responses using two different immunoassays. 6558 16-17-year-old females participated in the FUTURE II (NCT00092534) and PATRICIA (NCT00122681) trials in 2002-2004. Both the quadrivalent and bivalent vaccine recipients (QVR and BVR) received three doses. Twelve-year follow-up for 648 vaccinees was conducted by the Finnish Maternity Cohort. The presence of neutralising and binding HPV antibodies was analysed via HPV pseudovirion-based neutralisation and pseudovirion-binding assays. Four percent and 14.3
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39138224
%R 10.1038/s41541-024-00941-w
%U https://inrepo02.dkfz.de/record/292299