Journal Article

DKFZ-2024-01659

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lack of detectable HPV18 antibodies in 14% of quadrivalent vaccinees in a longitudinal cohort study.

Gray, P. ; Mariz, F. C. (First author)DKFZ* ; Eklund, C. ; Eriksson, T. ; Faust, H. ; Kann, H. ; Müller, M.DKFZ* ; Paavonen, J. ; Pimenoff, V. N. ; Sehr, P. ; Surcel, H.-M. ; Dillner, J. ; Waterboer, T.DKFZ* ; Lehtinen, M.

2024
Nature Publishing Group [London]

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Please use a persistent id in citations: doi:10.1038/s41541-024-00941-w

Abstract: Although HPV vaccines are highly efficacious, a notable proportion of quadrivalent vaccinees are HPV18 seronegative post-vaccination. We have investigated this findings' validity by comparing vaccine-induced antibody responses using two different immunoassays. 6558 16-17-year-old females participated in the FUTURE II (NCT00092534) and PATRICIA (NCT00122681) trials in 2002-2004. Both the quadrivalent and bivalent vaccine recipients (QVR and BVR) received three doses. Twelve-year follow-up for 648 vaccinees was conducted by the Finnish Maternity Cohort. The presence of neutralising and binding HPV antibodies was analysed via HPV pseudovirion-based neutralisation and pseudovirion-binding assays. Four percent and 14.3% of the QVRs were seronegative for neutralising and binding antibodies to HPV16 and HPV18, respectively. No BVRs were HPV16/18 seronegative post-vaccination. The antibody titres were strongly correlated between the assays, Pearson's correlation coefficient, r[HPV16] = 0.92 and 0.85, and r[HPV18] = 0.91 and 0.86 among the QVRs and BVRs respectively. Fourteen percent of QVRs lacked detectable HPV18 antibodies in long-term follow-up.

Note: #EA:D335#

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Contributing Institute(s):

1. Tumorvirus-spez. Vakzinierungsstrategie (D335)
2. Infektionen und Krebs-Epidemiologie (D320)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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