TY  - JOUR
AU  - Gray, Penelope
AU  - Mariz, Filipe Colaço
AU  - Eklund, Carina
AU  - Eriksson, Tiina
AU  - Faust, Helena
AU  - Kann, Hanna
AU  - Müller, Martin
AU  - Paavonen, Jorma
AU  - Pimenoff, Ville N
AU  - Sehr, Peter
AU  - Surcel, Heljä-Marja
AU  - Dillner, Joakim
AU  - Waterboer, Tim
AU  - Lehtinen, Matti
TI  - Lack of detectable HPV18 antibodies in 14
JO  - npj vaccines
VL  - 9
IS  - 1
SN  - 2059-0105
CY  - [London]
PB  - Nature Publishing Group
M1  - DKFZ-2024-01659
SP  - 146
PY  - 2024
N1  - #EA:D335#
AB  - Although HPV vaccines are highly efficacious, a notable proportion of quadrivalent vaccinees are HPV18 seronegative post-vaccination. We have investigated this findings' validity by comparing vaccine-induced antibody responses using two different immunoassays. 6558 16-17-year-old females participated in the FUTURE II (NCT00092534) and PATRICIA (NCT00122681) trials in 2002-2004. Both the quadrivalent and bivalent vaccine recipients (QVR and BVR) received three doses. Twelve-year follow-up for 648 vaccinees was conducted by the Finnish Maternity Cohort. The presence of neutralising and binding HPV antibodies was analysed via HPV pseudovirion-based neutralisation and pseudovirion-binding assays. Four percent and 14.3
LB  - PUB:(DE-HGF)16
C6  - pmid:39138224
DO  - DOI:10.1038/s41541-024-00941-w
UR  - https://inrepo02.dkfz.de/record/292299
ER  -