% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Gray:292299,
      author       = {P. Gray and F. C. Mariz$^*$ and C. Eklund and T. Eriksson
                      and H. Faust and H. Kann and M. Müller$^*$ and J. Paavonen
                      and V. N. Pimenoff and P. Sehr and H.-M. Surcel and J.
                      Dillner and T. Waterboer$^*$ and M. Lehtinen},
      title        = {{L}ack of detectable {HPV}18 antibodies in $14\%$ of
                      quadrivalent vaccinees in a longitudinal cohort study.},
      journal      = {npj vaccines},
      volume       = {9},
      number       = {1},
      issn         = {2059-0105},
      address      = {[London]},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2024-01659},
      pages        = {146},
      year         = {2024},
      note         = {#EA:D335#},
      abstract     = {Although HPV vaccines are highly efficacious, a notable
                      proportion of quadrivalent vaccinees are HPV18 seronegative
                      post-vaccination. We have investigated this findings'
                      validity by comparing vaccine-induced antibody responses
                      using two different immunoassays. 6558 16-17-year-old
                      females participated in the FUTURE II (NCT00092534) and
                      PATRICIA (NCT00122681) trials in 2002-2004. Both the
                      quadrivalent and bivalent vaccine recipients (QVR and BVR)
                      received three doses. Twelve-year follow-up for 648
                      vaccinees was conducted by the Finnish Maternity Cohort. The
                      presence of neutralising and binding HPV antibodies was
                      analysed via HPV pseudovirion-based neutralisation and
                      pseudovirion-binding assays. Four percent and $14.3\%$ of
                      the QVRs were seronegative for neutralising and binding
                      antibodies to HPV16 and HPV18, respectively. No BVRs were
                      HPV16/18 seronegative post-vaccination. The antibody titres
                      were strongly correlated between the assays, Pearson's
                      correlation coefficient, r[HPV16] = 0.92 and 0.85, and
                      r[HPV18] = 0.91 and 0.86 among the QVRs and BVRs
                      respectively. Fourteen percent of QVRs lacked detectable
                      HPV18 antibodies in long-term follow-up.},
      cin          = {D335 / D320},
      ddc          = {610},
      cid          = {I:(DE-He78)D335-20160331 / I:(DE-He78)D320-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39138224},
      doi          = {10.1038/s41541-024-00941-w},
      url          = {https://inrepo02.dkfz.de/record/292299},
}