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000292327 037__ $$aDKFZ-2024-01678
000292327 041__ $$aGerman
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000292327 1001_ $$aHolze, Magdalena$$b0
000292327 245__ $$aSex differences in pancreatic cancer.[Geschlechtsunterschiede beim Pankreaskarzinom.]
000292327 260__ $$a[Berlin]$$bSpringer Medizin Verlag GmbH$$c2024
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000292327 520__ $$aThis review article discusses the currently available evidence on the importance of biological and social sex in pancreatic cancer in the context of the operative, perioperative and multimodal treatment. In pancreatic cancer there are gender differences with respect to the incidence, treatment response and prognosis. Sex significantly influences both innate and adaptive immune responses, thereby affecting treatment response and survival rates. Women are less likely to receive systemic treatment and tend to wait longer for surgery but have better perioperative outcomes after pancreatic resection. Overall, female pancreatic cancer patients seem to have longer survival under treatment; however, they report a subjectively lower quality of life and higher disease burden.
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000292327 650_7 $$2Other$$aGender medicine
000292327 650_7 $$2Other$$aImmune response
000292327 650_7 $$2Other$$aPancreatic surgery
000292327 650_7 $$2Other$$aPrecision medicine
000292327 650_7 $$2Other$$aTreatment response
000292327 7001_ $$0P:(DE-He78)bac8c2c56238485ecf0475ff14438430$$aAhmed, Azaz$$b1$$udkfz
000292327 7001_ $$aLoos, Martin$$b2
000292327 7001_ $$aMichalski, Christoph W$$b3
000292327 7001_ $$aKlotz, Rosa$$b4
000292327 773__ $$0PERI:(DE-600)3120893-9$$a10.1007/s00104-024-02150-6$$gVol. 95, no. 9, p. 709 - 714$$n9$$p709 - 714$$tDie Chirurgie$$v95$$x2731-6971$$y2024
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