Journal Article (Review Article)

DKFZ-2024-01678

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sex differences in pancreatic cancer.[Geschlechtsunterschiede beim Pankreaskarzinom.]

Holze, M. ; Ahmed, A.DKFZ* ; Loos, M. ; Michalski, C. W. ; Klotz, R.

2024
Springer Medizin Verlag GmbH [Berlin]

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Please use a persistent id in citations: doi:10.1007/s00104-024-02150-6

Abstract: This review article discusses the currently available evidence on the importance of biological and social sex in pancreatic cancer in the context of the operative, perioperative and multimodal treatment. In pancreatic cancer there are gender differences with respect to the incidence, treatment response and prognosis. Sex significantly influences both innate and adaptive immune responses, thereby affecting treatment response and survival rates. Women are less likely to receive systemic treatment and tend to wait longer for surgery but have better perioperative outcomes after pancreatic resection. Overall, female pancreatic cancer patients seem to have longer survival under treatment; however, they report a subjectively lower quality of life and higher disease burden.

Keyword(s): Gender medicine ; Immune response ; Pancreatic surgery ; Precision medicine ; Treatment response

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Contributing Institute(s):

1. Translationale Immuntherapie (D196)

Research Program(s):

1. 314 - Immunologie und Krebs (POF4-314) (POF4-314)

Appears in the scientific report 2024

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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