TY  - JOUR
AU  - Holze, Magdalena
AU  - Ahmed, Azaz
AU  - Loos, Martin
AU  - Michalski, Christoph W
AU  - Klotz, Rosa
TI  - Sex differences in pancreatic cancer.[Geschlechtsunterschiede beim Pankreaskarzinom.]
JO  - Die Chirurgie
VL  - 95
IS  - 9
SN  - 2731-6971
CY  - [Berlin]
PB  - Springer Medizin Verlag GmbH
M1  - DKFZ-2024-01678
SP  - 709 - 714
PY  - 2024
AB  - This review article discusses the currently available evidence on the importance of biological and social sex in pancreatic cancer in the context of the operative, perioperative and multimodal treatment. In pancreatic cancer there are gender differences with respect to the incidence, treatment response and prognosis. Sex significantly influences both innate and adaptive immune responses, thereby affecting treatment response and survival rates. Women are less likely to receive systemic treatment and tend to wait longer for surgery but have better perioperative outcomes after pancreatic resection. Overall, female pancreatic cancer patients seem to have longer survival under treatment; however, they report a subjectively lower quality of life and higher disease burden.
KW  - Gender medicine (Other)
KW  - Immune response (Other)
KW  - Pancreatic surgery (Other)
KW  - Precision medicine (Other)
KW  - Treatment response (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39145868
DO  - DOI:10.1007/s00104-024-02150-6
UR  - https://inrepo02.dkfz.de/record/292327
ER  -